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    sh3glb2b SH3-domain GRB2-like endophilin B2b [ Danio rerio (zebrafish) ]

    Gene ID: 394094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sh3glb2bprovided by ZNC
    Official Full Name
    SH3-domain GRB2-like endophilin B2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-833
    See related
    Ensembl:ENSDARG00000035470 AllianceGenome:ZFIN:ZDB-GENE-040426-833
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sh3glb2; zgc:55887
    Summary
    Predicted to be involved in membrane organization. Predicted to be located in cytoplasm. Predicted to be active in membrane. Is expressed in central nervous system; eye; immature eye; lens; and solid lens vesicle. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sh3glb2b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31644448..31689882, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31044295..31089799, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkey-220k22.3 Neighboring gene uncharacterized LOC100535208 Neighboring gene uncharacterized LOC101883628 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55887

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endophilin-B2b
    Names
    SH3-domain GRB2-like endophilin B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201119.1 → NP_957413.1  endophilin-B2b

      See identical proteins and their annotated locations for NP_957413.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047195
      UniProtKB/TrEMBL
      A0A8N1Z3P9, Q802U5
      Related
      ENSDARP00000088944.4, ENSDART00000098172.6
      Conserved Domains (2) summary
      cd11944
      Location:317 → 371
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 249
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      31644448..31689882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221124.1 → XP_068077225.1  endophilin-B2b isoform X8

    2. XM_021476047.2 → XP_021331722.1  endophilin-B2b isoform X6

      UniProtKB/TrEMBL
      A0A2R8QMQ9, A0A8M9PJT5
      Related
      ENSDARP00000155783.1, ENSDART00000190229.1
      Conserved Domains (2) summary
      cd07617
      Location:21 → 270
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:338 → 392
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    3. XM_005171809.5 → XP_005171866.1  endophilin-B2b isoform X4

      UniProtKB/TrEMBL
      A0A8M2BJ56, A2CEP2
      Related
      ENSDARP00000114502.1, ENSDART00000147065.3
      Conserved Domains (2) summary
      cd07617
      Location:21 → 278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:346 → 400
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    4. XM_021476045.2 → XP_021331720.1  endophilin-B2b isoform X2

      UniProtKB/TrEMBL
      A0A8M9QDN1
      Conserved Domains (2) summary
      cd11944
      Location:361 → 415
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 293
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_021476049.2 → XP_021331724.1  endophilin-B2b isoform X9

      UniProtKB/TrEMBL
      A0A8M9Q307
      Conserved Domains (2) summary
      cd11944
      Location:321 → 375
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 253
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_021476048.2 → XP_021331723.1  endophilin-B2b isoform X7

      UniProtKB/TrEMBL
      A0A8M9PX86
      Conserved Domains (2) summary
      cd07617
      Location:21 → 261
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:329 → 383
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    7. XM_021476046.2 → XP_021331721.1  endophilin-B2b isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q8B5
      Conserved Domains (2) summary
      cd11944
      Location:342 → 396
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 274
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. XM_005171808.5 → XP_005171865.1  endophilin-B2b isoform X3

      UniProtKB/TrEMBL
      A0A2R8Q0C3, A0A8M2BJ23
      Related
      ENSDARP00000146608.1, ENSDART00000184319.1
      Conserved Domains (2) summary
      cd11944
      Location:350 → 404
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 282
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_021476044.2 → XP_021331719.1  endophilin-B2b isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q303
      Conserved Domains (2) summary
      cd11944
      Location:365 → 419
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:21 → 297
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394584.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      292507..331080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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