guca1aa guanylate cyclase activator 1Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: guca1aaprovided by ZNC
Official Full Name: guanylate cyclase activator 1Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011128-5
See related: Ensembl:ENSDARG00000010454 AllianceGenome:ZFIN:ZDB-GENE-011128-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gcap1; guca1a
Summary: Enables calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (22343093..22350227)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (22622127..22629252)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural Insights into Retinal Guanylate Cyclase Activator Proteins (GCAPs).
Title: Structural Insights into Retinal Guanylate Cyclase Activator Proteins (GCAPs).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium sensitive guanylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylyl cyclase-activating protein 1

Names: guanylate cyclase activator 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131870.2 → NP_571945.2 guanylyl cyclase-activating protein 1

Status: VALIDATED

Source sequence(s)

BX537162

UniProtKB/TrEMBL

Q90WX4

Related

ENSDARP00000020242.6, ENSDART00000023588.8