ncf4 neutrophil cytosolic factor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncf4provided by ZNC
Official Full Name: neutrophil cytosolic factor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-041124-1
See related: Ensembl:ENSDARG00000040812 AllianceGenome:ZFIN:ZDB-GENE-041124-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to act upstream of or within phagocytosis and respiratory burst. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (29204885..29252049)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (29255433..29302854)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory burst	IEA Inferred from Electronic Annotation more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neutrophil cytosol factor 4

Names: p40phox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205711.2 → NP_991274.2 neutrophil cytosol factor 4

Status: VALIDATED

Source sequence(s)

BX649427, BX927116

UniProtKB/TrEMBL

A0A8M1PK50, Q1LUW2

Related

ENSDARP00000059819.5, ENSDART00000059820.7

Conserved Domains (3) summary

cd06399
Location:250 → 345

PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...

cd06882
Location:19 → 141

PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase

cd11869
Location:171 → 224

SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase