slc30a1a solute carrier family 30 member 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc30a1aprovided by ZNC
Official Full Name: solute carrier family 30 member 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1840
See related: Ensembl:ENSDARG00000005463 AllianceGenome:ZFIN:ZDB-GENE-040426-1840
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: slc30a1; zgc:77589
Summary: Predicted to enable calcium channel inhibitor activity and zinc ion transmembrane transporter activity. Acts upstream of or within response to zinc ion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in central nervous system; hatching gland; and yolk syncytial layer. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (13894076..13913790)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (13998112..14017810)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
Title: Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
Downregulation of ZnT1 as well as the overexpression of ZIP10, in responses to the ovarian Zn depletion induced by Cd, play a major role in Cd accumulation and consequently in its reproductive toxicity.
Title: Cadmium-induced ovarian pathophysiology is mediated by change in gene expression pattern of zinc transporters in zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within zinc ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc transporter 1a

Names: ZnT1; solute carrier family 30 (zinc transporter), member 1; solute carrier family 30 (zinc transporter), member 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200879.1 → NP_957173.1 zinc transporter 1a

See identical proteins and their annotated locations for NP_957173.1

Status: PROVISIONAL

Source sequence(s)

BC063939

UniProtKB/TrEMBL

A0A8M1PF72, Q6P3M0

Related

ENSDARP00000022487.4, ENSDART00000007744.5

Conserved Domains (2) summary

COG1230
Location:5 → 411

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:19 → 118

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

13894076..13913790

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160431.5 → XP_005160488.1 zinc transporter 1a isoform X1

UniProtKB/TrEMBL

A0A8M2B789

Conserved Domains (2) summary

COG1230
Location:5 → 414

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:19 → 118

Cation_efflux; Cation efflux family