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    mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 724006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mgat5provided by ZNC
    Official Full Name
    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060616-238
    See related
    Ensembl:ENSDARG00000071506 AllianceGenome:ZFIN:ZDB-GENE-060616-238
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mgat5a; zgc:136939; si:dkeyp-4h4.2
    Summary
    Predicted to enable alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within neuromast hair cell differentiation involved in neuromast regeneration. Predicted to be located in Golgi membrane and extracellular region. Predicted to be active in Golgi apparatus. Is expressed in gut and nervous system. Orthologous to human MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mgat5 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (11972820..12091448)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (11943138..12061766)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene muscle RAS oncogene homolog b Neighboring gene parathyroid hormone 2 receptor b Neighboring gene transmembrane protein 163b Neighboring gene uncharacterized LOC137488913 Neighboring gene cyclin T2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish. Pei W, et al. Cell Regen, 2016. PMID 27795824, Free PMC Article
    2. Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. Pei W, et al. NPJ Regen Med, 2018. PMID 29872546, Free PMC Article
    3. In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Clark KJ, et al. Nat Methods, 2011 Jun. PMID 21552255, Free PMC Article
    4. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuromast hair cell differentiation involved in neuromast regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
    Names
    mannoside acetylglucosaminyltransferase 5
    mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
    NP_001038776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045311.1 → NP_001038776.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

      See identical proteins and their annotated locations for NP_001038776.1

      Status: PROVISIONAL

      Source sequence(s)
      BC117664
      UniProtKB/TrEMBL
      A0A8M1NAP4, Q1ECU6
      Related
      ENSDARP00000096566.4, ENSDART00000105788.5
      Conserved Domains (2) summary
      pfam15024
      Location:173 → 727
      Glyco_transf_18; Glycosyltransferase family 18
      pfam15027
      Location:3 → 139
      DUF4525; Domain of unknown function (DUF4525)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      11972820..12091448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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