U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cyp27c1 cytochrome P450, family 27, subfamily C, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 558396, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cyp27c1provided by ZNC
    Official Full Name
    cytochrome P450, family 27, subfamily C, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-68
    See related
    Ensembl:ENSDARG00000092660 AllianceGenome:ZFIN:ZDB-GENE-080204-68
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu635; zgc:172278
    Summary
    Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and retinoid binding activity. Predicted to be involved in lipid metabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; immature eye; margin; neural tube; and yolk syncytial layer. Orthologous to human CYP27C1 (cytochrome P450 family 27 subfamily C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cyp27c1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9568149..9581986, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9332610..9346407, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 27 subfamily A member 2 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene excision repair cross-complementation group 3 Neighboring gene WD repeat domain 12

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Enright JM, et al. Curr Biol, 2015 Dec 7. PMID 26549260, Free PMC Article
    2. Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio). Chun RF, et al. Cell Biochem Funct, 2014 Dec. PMID 25290078, Free PMC Article
    3. Endocrine regulation of multichromatic color vision. Mackin RD, et al. Proc Natl Acad Sci U S A, 2019 Aug 20. PMID 31383755, Free PMC Article
    4. Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Brown JL, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18719100, Free PMC Article
    5. Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Volkov LI, et al. Proc Natl Acad Sci U S A, 2020 Jun 30. PMID 32541022, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC172278

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables all-trans retinal 3,4-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans retinoic acid 3,4-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans retinol 3,4-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome P450 27C1
    Names
    all-trans retinol 3,4-desaturase
    NP_001106808.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113337.3 → NP_001106808.2  cytochrome P450 27C1

      Status: VALIDATED

      Source sequence(s)
      BX927387
      UniProtKB/Swiss-Prot
      A8WGA0, F1QMI2
      Related
      ENSDARP00000118349.1, ENSDART00000144335.2
      Conserved Domains (1) summary
      pfam00067
      Location:74 → 517
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      9568149..9581986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8WGA0.2 GenPept UniProtKB/Swiss-Prot:A8WGA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.