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    atp2b2 ATPase plasma membrane Ca2+ transporting 2 [ Danio rerio (zebrafish) ]

    Gene ID: 557430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atp2b2provided by ZNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061016-1
    See related
    Ensembl:ENSDARG00000063433 AllianceGenome:ZFIN:ZDB-GENE-061016-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable P-type calcium transporter activity. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in intracellular membrane-bounded organelle and postsynaptic density membrane. Is expressed in several structures, including blood; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See atp2b2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (1147386..1291369, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (1122113..1306155, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100003140 Neighboring gene uncharacterized LOC137496749 Neighboring gene solute carrier family 6 member 11b Neighboring gene isoleucyl-tRNA synthetase 1 Neighboring gene transfer RNA glutamic acid (anticodon UUC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. Tseng DY, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Mar. PMID 19073903
    2. Hydrogen sulfide promotes calcium uptake in larval zebrafish. Kwong RW, et al. Am J Physiol Cell Physiol, 2015 Jul 1. PMID 25948733, Free PMC Article
    3. Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia-inducible factor. Kwong RW, et al. J Exp Biol, 2016 Dec 15. PMID 27802147
    4. Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Kwong RW, et al. Am J Physiol Regul Integr Comp Physiol, 2014 Feb 15. PMID 24381181, Free PMC Article
    5. Action of vitamin D and the receptor, VDRa, in calcium handling in zebrafish (Danio rerio). Lin CH, et al. PLoS One, 2012. PMID 23029160, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 2
    Names
    ATPase, Ca++ transporting, plasma membrane 2
    plasma membrane calcium ATPase
    pmca2
    NP_001116710.1
    XP_068080278.1
    XP_068080279.1
    XP_068080280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123238.1 → NP_001116710.1  plasma membrane calcium-transporting ATPase 2

      See identical proteins and their annotated locations for NP_001116710.1

      Status: PROVISIONAL

      Source sequence(s)
      EU559282
      UniProtKB/TrEMBL
      A0A8M9QD45, B2CZB8
      Related
      ENSDARP00000129987.1, ENSDART00000158390.2
      Conserved Domains (7) summary
      TIGR01517
      Location:9 → 1096
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:191 → 499
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:914 → 1092
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:48 → 115
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1137 → 1184
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:657 → 840
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:560 → 649
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      1147386..1291369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224179.1 → XP_068080280.1  plasma membrane calcium-transporting ATPase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QD45

    2. XM_068224178.1 → XP_068080279.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QD45

    3. XM_068224177.1 → XP_068080278.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QD45
    Nucleotide Protein
    Heading Accession and Version

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