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    vamp4 vesicle-associated membrane protein 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vamp4provided by ZNC
    Official Full Name
    vesicle-associated membrane protein 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-92
    See related
    Ensembl:ENSDARG00000043510 AllianceGenome:ZFIN:ZDB-GENE-040625-92
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73166; zgc:86855
    Summary
    Predicted to be involved in SNARE complex assembly. Predicted to act upstream of or within Golgi ribbon formation and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in trans-Golgi network. Is expressed in central nervous system. Orthologous to human VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See vamp4 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (14968078..15005119)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (15072037..15109139)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Neighboring gene myocilin Neighboring gene proline-rich coiled-coil 2C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. Rauwerda H, et al. PLoS One, 2016. PMID 26799215, Free PMC Article
    2. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    3. Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Biswas G, et al. Mar Genomics, 2015 Aug. PMID 25792259
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73166

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi ribbon formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-associated membrane protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433724.1 → NP_001420653.1  vesicle-associated membrane protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CABZ01063328, FP074855, FP102015
      UniProtKB/TrEMBL
      A0A8M1PFQ0, A0A8M3ALD9, F6P4N7, Q6IQB0

    2. NM_001433725.1 → NP_001420654.1  vesicle-associated membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CABZ01063328, FP074855, FP102015
      UniProtKB/TrEMBL
      A0A8M1PFQ0, F6P4N7

    3. NM_200735.3 → NP_957029.3  vesicle-associated membrane protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CABZ01063328, FP074855, FP102015
      UniProtKB/TrEMBL
      A0A8M1PFQ0, A0A8M3ALD9, F6P4N7, Q6IQB0
      Related
      ENSDARP00000063873.6, ENSDART00000063874.7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      14968078..15005119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294594.4 → XP_009292869.1  vesicle-associated membrane protein 4 isoform X1

      Related
      ENSDARP00000148329.1, ENSDART00000190910.1
      Conserved Domains (2) summary
      cd15869
      Location:50 → 116
      R-SNARE_VAMP4; SNARE motif of VAMP4
      pfam00957
      Location:49 → 118
      Synaptobrevin; Synaptobrevin
    Nucleotide Protein Strain
    Heading Accession and Version

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