gabrb2a gamma-aminobutyric acid type A receptor subunit beta2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gabrb2aprovided by ZNC
Official Full Name: gamma-aminobutyric acid type A receptor subunit beta2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8196
See related: Ensembl:ENSDARG00000079586 AllianceGenome:ZFIN:ZDB-GENE-030131-8196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gabrb2; fj59e04; gabaabeta2; wu:fj59e04; zgc:136311; si:ch211-215g18.1
Summary: Contributes to GABA-gated chloride ion channel activity. Acts upstream of or within protein heterotrimerization. Predicted to be located in membrane. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; brainstem; and eye. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (22172080..22273845)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (21874855..21976600)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of zebrafish GABAA receptor subunits.
Title: Characterization of zebrafish GABA(A) receptor subunits.
Results provide plausible epigenetic evidence of the GABAA receptor beta2 subunit involvement in the schizophrenia-like behaviors and demonstrate the potential use of zebrafish models in neuropsychiatric research.
Title: DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms.

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General gene information

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Markers

fj59e04.x1 (e-PCR)
- UniSTS:188721

G46515 (e-PCR)
- UniSTS:107317

fb11d03.x1 (e-PCR)
- UniSTS:202834

fa03a04.s1 (e-PCR)
- UniSTS:202155

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to GABA-gated chloride ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein heterotrimerization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit beta-2a

Names: GABAA receptor betaZ2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid (GABA) A receptor, beta 2a; gamma-aminobutyric acid A receptor, beta 2; gamma-aminobutyric acid type A receptor beta2 subunit a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024387.2 → NP_001019558.2 gamma-aminobutyric acid receptor subunit beta-2a precursor

Status: VALIDATED

Source sequence(s)

AJ302649, BC115078, BX120008, EB940834, EE690598

UniProtKB/TrEMBL

A0A8M1N6N1, Q9DDD9

Related

ENSDARP00000104215.3, ENSDART00000114750.4

Conserved Domains (1) summary

TIGR00860
Location:7 → 517

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

22172080..22273845

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173103.4 → XP_005173160.1 gamma-aminobutyric acid receptor subunit beta-2a isoform X1

UniProtKB/TrEMBL

A0A8M2BKD0, A4FUK8, Q9DDD9

Conserved Domains (3) summary

TIGR00860
Location:7 → 470

LIC; Cation transporter family protein

pfam02931
Location:39 → 241

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:248 → 467

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region