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    nek2 NIMA-related kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 394025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nek2provided by ZNC
    Official Full Name
    NIMA-related kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-752
    See related
    Ensembl:ENSDARG00000005619 AllianceGenome:ZFIN:ZDB-GENE-040426-752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55602
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within retinal rod cell development. Predicted to be active in centrosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nek2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13883165..13893910)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13987185..13997930)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene opsin 8, group member c Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene solute carrier family 30 member 1a Neighboring gene si:dkey-249p7.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene. Nishiguchi KM, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043777, Free PMC Article
    2. Effects of Dietary Supplementation with Aurantiochytrium sp. on Zebrafish Growth as Determined by Transcriptomics. Yang H, et al. Animals (Basel), 2022 Oct 16. PMID 36290180, Free PMC Article
    3. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Zhong H, et al. Mol Biosyst, 2009 Nov. PMID 19823752, Free PMC Article
    4. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55602

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retinal rod cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal rod cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek2
    Names
    NIMA (never in mitosis gene a)-related kinase 2
    NP_957344.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201050.1 → NP_957344.1  serine/threonine-protein kinase Nek2

      See identical proteins and their annotated locations for NP_957344.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048055
      UniProtKB/TrEMBL
      A0A2R8Q6P9, F6P194, Q7ZUN2
      Related
      ENSDARP00000020452.5, ENSDART00000003248.8
      Conserved Domains (2) summary
      smart00220
      Location:8 → 267
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7 → 271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      13883165..13893910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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