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    cstf2 cleavage stimulation factor, 3' pre-RNA, subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 386806, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cstf2provided by ZNC
    Official Full Name
    cleavage stimulation factor, 3' pre-RNA, subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031118-2
    See related
    Ensembl:ENSDARG00000090788 AllianceGenome:ZFIN:ZDB-GENE-031118-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    CstF-64; fb11e07; zgc:56346; zgc:77730; wu:fb11e07
    Summary
    Predicted to enable mRNA binding activity. Predicted to act upstream of or within mRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to several human genes including CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cstf2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (41361858..41388167, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (40994604..41020924, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene XK related X-linked Neighboring gene NADPH oxidase 1 Neighboring gene transfer RNA valine (anticodon UAC) Neighboring gene BCL6 corepressor-like 1 Neighboring gene uncharacterized LOC110440210

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif. Salisbury J, et al. BMC Genomics, 2006 Mar 16. PMID 16542450, Free PMC Article
    2. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
    3. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Bai X, et al. Cell, 2010 Jul 9. PMID 20603019, Free PMC Article
    4. The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains. Desai S, et al. BMC Evol Biol, 2008 Jun 19. PMID 18565225, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage stimulation factor subunit 2
    Names
    cleavage stimulation factor 64 kilodalton subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200114.2 → NP_956408.2  cleavage stimulation factor subunit 2

      See identical proteins and their annotated locations for NP_956408.2

      Status: PROVISIONAL

      Source sequence(s)
      BC065442
      UniProtKB/TrEMBL
      Q6P0U7
      Related
      ENSDARP00000110939.1, ENSDART00000124532.4
      Conserved Domains (5) summary
      PHA03195
      Location:273 → 339
      PHA03195; tegument protein VP11/12; Provisional
      COG0724
      Location:24 → 112
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12671
      Location:26 → 100
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:444 → 484
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:121 → 199
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      41361858..41388167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291098.4 → XP_009289373.1  cleavage stimulation factor subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0R4I9I2, A0A8M3AHX3
      Related
      ENSDARP00000129952.1, ENSDART00000169247.2
      Conserved Domains (4) summary
      COG0724
      Location:24 → 112
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12671
      Location:26 → 100
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:464 → 504
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:121 → 199
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    Nucleotide Protein Strain
    Heading Accession and Version

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