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    lmna lamin A [ Danio rerio (zebrafish) ]

    Gene ID: 195815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmnaprovided by ZNC
    Official Full Name
    lamin Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020424-3
    See related
    Ensembl:ENSDARG00000013415 AllianceGenome:ZFIN:ZDB-GENE-020424-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb948; wu:fk66d12
    Summary
    Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within several processes, including heart contraction; regulation of cellular senescence; and skeletal muscle tissue development. Predicted to be located in intermediate filament; nuclear matrix; and nucleoplasm. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in several structures, including fin; head; mesoderm; musculature system; and pleuroperitoneal region. Used to study muscle tissue disease. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lmna in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30521632..30569571, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30562930..30611687, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 7 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene melanocortin 2 receptor Neighboring gene melanocortin 5b receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of tissue-specific regulatory region in the zebrafish lamin A promoter. Verma AD, et al. Gene, 2015 Aug 1. PMID 25921963
    2. Specific RNAi mediated gene knockdown in zebrafish cell lines. Gruber J, et al. RNA Biol, 2005 Jul-Sep. PMID 17114924
    3. Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases. Hayashi K, et al. Cardiovasc Res, 2020 Nov 1. PMID 31977013, Free PMC Article
    4. Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9. Prykhozhij SV, et al. Nucleic Acids Res, 2018 Sep 28. PMID 29905858, Free PMC Article
    5. A CRISPR/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy. Nicolas HA, et al. Dev Dyn, 2022 Apr. PMID 34599606

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lamin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152971.1 → NP_694503.1  lamin

      See identical proteins and their annotated locations for NP_694503.1

      Status: PROVISIONAL

      Source sequence(s)
      AF397016
      UniProtKB/TrEMBL
      Q90XD7
      Related
      ENSDARP00000153174.1, ENSDART00000191716.1
      Conserved Domains (6) summary
      pfam00038
      Location:27 → 383
      Filament; Intermediate filament protein
      pfam00932
      Location:451 → 559
      LTD; Lamin Tail Domain
      pfam02601
      Location:322 → 400
      Exonuc_VII_L; Exonuclease VII, large subunit
      pfam04871
      Location:102 → 202
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam06156
      Location:295 → 359
      DUF972; Protein of unknown function (DUF972)
      cl12013
      Location:237 → 350
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      30521632..30569571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158168.5 → XP_005158225.1  lamin isoform X1

      See identical proteins and their annotated locations for XP_005158225.1

      UniProtKB/TrEMBL
      B3DKC5, B3DKD3
      Related
      ENSDARP00000145959.1, ENSDART00000191040.1
      Conserved Domains (6) summary
      pfam00038
      Location:27 → 383
      Filament; Intermediate filament protein
      pfam00932
      Location:451 → 559
      LTD; Lamin Tail Domain
      pfam02601
      Location:322 → 400
      Exonuc_VII_L; Exonuclease VII, large subunit
      pfam04871
      Location:102 → 202
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam06156
      Location:295 → 359
      DUF972; Protein of unknown function (DUF972)
      cl12013
      Location:237 → 350
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_005158167.5 → XP_005158224.1  lamin isoform X1

      See identical proteins and their annotated locations for XP_005158224.1

      UniProtKB/TrEMBL
      B3DKC5, B3DKD3
      Related
      ENSDARP00000113049.1, ENSDART00000145087.2
      Conserved Domains (6) summary
      pfam00038
      Location:27 → 383
      Filament; Intermediate filament protein
      pfam00932
      Location:451 → 559
      LTD; Lamin Tail Domain
      pfam02601
      Location:322 → 400
      Exonuc_VII_L; Exonuclease VII, large subunit
      pfam04871
      Location:102 → 202
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
      pfam06156
      Location:295 → 359
      DUF972; Protein of unknown function (DUF972)
      cl12013
      Location:237 → 350
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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