Gpr4 G protein-coupled receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr4provided by MGI
Official Full Name: G protein-coupled receptor 4provided by MGI
Primary source: MGI:MGI:2441992
See related: Ensembl:ENSMUSG00000044317 AllianceGenome:MGI:2441992
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be active in plasma membrane. Is expressed in cerebral cortex. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 11.4), subcutaneous fat pad adult (RPKM 11.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.46 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18946463..18958101)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19212538..19224176)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
Title: The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling.
The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson's Disease.
Title: The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson's Disease.
Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.
Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues.
Title: GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.
GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
Title: GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP.
Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin-angiotensin system.
Title: Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.
knockdown of a proton-sensing G protein-coupled receptor GPR4 markedly reduced CHOP expression and endothelial cell apoptosis after hypoxia exposure.
Title: Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.
required for maintenance of normal acid-base homeostasis
Title: Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.
The results indicate that through the G12/13/Rho signaling pathway GPR4 modulates focal adhesion dynamics and reduces cell spreading and membrane ruffling.
Title: GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway.
The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
Title: PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

UniSTS:498495 (e-PCR)
- UniSTS:498495

Gpr4 (e-PCR), detects polymorphism
- UniSTS:498495

Gpr4 (e-PCR), detects polymorphism
- UniSTS:546803

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within angiogenesis involved in wound healing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glomerular mesangial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acidic pH	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175668.4 → NP_783599.1 G-protein coupled receptor 4

See identical proteins and their annotated locations for NP_783599.1

Status: VALIDATED

Source sequence(s)

AC148988

Consensus CDS

CCDS20893.1

UniProtKB/Swiss-Prot

Q8BUD0

Related

ENSMUSP00000061243.5, ENSMUST00000060225.6

Conserved Domains (2) summary

pfam00001
Location:37 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:28 → 145

7tm_4; Olfactory receptor