Clca2 chloride channel accessory 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clca2provided by MGI
Official Full Name: chloride channel accessory 2provided by MGI
Primary source: MGI:MGI:2139758
See related: Ensembl:ENSMUSG00000036960 AllianceGenome:MGI:2139758
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clca5; 4732440A06
Summary: This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]
Expression: Biased expression in bladder adult (RPKM 1.1), subcutaneous fat pad adult (RPKM 0.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 69.31 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (144776021..144805204, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (145070260..145099443, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLCA2 knockdown promoted keratinocyte apoptosis induced by hyperosmotic stress through impairment of cell-cell adhesion.
Title: Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.
Stat3-mediated regulation of expression of members of the calcium-activated chloride channel regulator (CLCA) family of proteins during involution and mammary carcinogenesis.
Title: Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue.
basal NF-kappaB activity is involved in the Ca(2+)-dependent regulation of mCLCA2 expression in a mouse keratinocyte line
Title: NF-κB-regulated transcriptional control of CLCA in a differentiated mouse keratinocyte line.
The results imply that mCLCA5 may play a role in maturation and keratinization of squamous epithelial cells.
Title: Murine mCLCA5 is expressed in granular layer keratinocytes of stratified epithelia.
results establish mCLCA5 as the mouse ortholog of hCLCA2, demonstrate that mCLCA5 is a detachment-sensitive growth inhibitor, and suggest a mechanism whereby these channels may antagonize mammary tumor progression, metastases [CLCA5]
Title: Re-expression of detachment-inducible chloride channel mCLCA5 suppresses growth of metastatic breast cancer cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

Clca5 (e-PCR), detects polymorphism
- UniSTS:495951

AI586120 (e-PCR)
- UniSTS:165302

BE199161 (e-PCR)
- UniSTS:207573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chloride transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-activated chloride channel regulator 2

Names: calcium-activated chloride channel family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409792.1 → NP_001396721.1 calcium-activated chloride channel regulator 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC152400

Related

ENSMUSP00000143161.2, ENSMUST00000198993.2
NM_178697.6 → NP_848812.1 calcium-activated chloride channel regulator 2 isoform 1

See identical proteins and their annotated locations for NP_848812.1

Status: REVIEWED

Source sequence(s)

AC152400

Consensus CDS

CCDS17890.1

UniProtKB/Swiss-Prot

Q8BG22, Q8BZF7

Related

ENSMUSP00000036029.7, ENSMUST00000040465.11

Conserved Domains (2) summary

cd00198
Location:310 → 466

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam08434
Location:34 → 893

CLCA; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

144776021..144805204 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501432.4 → XP_006501495.1 calcium-activated chloride channel regulator 2 isoform X1

Conserved Domains (1) summary

TIGR00868
Location:1 → 818

hCaCC; calcium-activated chloride channel protein 1
XM_006501433.1 → XP_006501496.1 calcium-activated chloride channel regulator 2 isoform X2

Conserved Domains (1) summary

TIGR00868
Location:11 → 689

hCaCC; calcium-activated chloride channel protein 1