Sec24b SEC24 homolog B, COPII coat complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec24bprovided by MGI
Official Full Name: SEC24 homolog B, COPII coat complex componentprovided by MGI
Primary source: MGI:MGI:2139764
See related: Ensembl:ENSMUSG00000001052 AllianceGenome:MGI:2139764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SEC24
Summary: Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within several processes, including artery morphogenesis; nervous system development; and regulation of establishment of planar polarity involved in neural tube closure. Part of COPII vesicle coat. Is expressed in cochlear duct and embryo. Orthologous to human SEC24B (SEC24 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 37.4), thymus adult (RPKM 21.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 59.87 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (129776408..129855248, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (129982759..130061599, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Title: Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Data present evidence that Sec24b deficiency specifically affects transport of the planar cell polarity core protein Vangl2, based on experiments in embryos and in cultured primary cells.
Title: Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auditory receptor cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cochlear nucleus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlear nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pulmonary artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of planar polarity involved in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	IDA Inferred from Direct Assay more info	PubMed
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein transport protein Sec24B

Names: Sec24 related gene family, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411432.1 → NP_001398361.1 protein transport protein Sec24B isoform 2

Status: VALIDATED

Source sequence(s)

AC118620
NM_001411433.1 → NP_001398362.1 protein transport protein Sec24B isoform 3

Status: VALIDATED

Source sequence(s)

AC118620

UniProtKB/TrEMBL

Q3UDH4
NM_207209.4 → NP_997092.1 protein transport protein Sec24B isoform 1

See identical proteins and their annotated locations for NP_997092.1

Status: VALIDATED

Source sequence(s)

AC118620

Consensus CDS

CCDS17840.1

UniProtKB/TrEMBL

Q80ZX0

Related

ENSMUSP00000001079.9, ENSMUST00000001079.15

Conserved Domains (6) summary

cd01479
Location:658 → 901

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:1122 → 1197

Gelsolin; Gelsolin repeat

pfam04810
Location:585 → 621

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:1001 → 1096

Sec23_helical; Sec23/Sec24 helical domain

pfam07223
Location:27 → 226

DUF1421; Protein of unknown function (DUF1421)

pfam08033
Location:902 → 986

Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

129776408..129855248 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163481.1 → XP_036019374.1 protein transport protein Sec24B isoform X2

UniProtKB/TrEMBL

Q3UDH4

Conserved Domains (1) summary

COG5028
Location:478 → 1210

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]