Gng5 G protein subunit gamma 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gng5provided by MGI
Official Full Name: G protein subunit gamma 5provided by MGI
Primary source: MGI:MGI:109164
See related: Ensembl:ENSMUSG00000068523 AllianceGenome:MGI:109164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G(y)5
Summary: Predicted to enable G-protein beta-subunit binding activity and PDZ domain binding activity. Acts upstream of or within positive regulation of neural precursor cell proliferation and positive regulation of secondary heart field cardioblast proliferation. Located in mitochondrion. Is expressed in several structures, including cerebellum; early conceptus; oocyte; and retina. Orthologous to human GNG5 (G protein subunit gamma 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 121.2), testis adult (RPKM 120.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 71.54 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146205591..146211298)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146499836..146505543)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/beta-catenin pathway.
Title: G protein subunit gamma 5 promotes the proliferation, metastasis and glycolysis of breast cancer cells through the Wnt/β-catenin pathway.
Targeted disruption of the mouse Gng5 gene encoding the gamma5 subtype produces embryonic lethality associated with severe head and heart defects.
Title: Disruption of G-protein γ5 subtype causes embryonic lethality in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gng5 (e-PCR), detects polymorphism
- UniSTS:496687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G-protein beta/gamma-subunit complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Names: guanine nucleotide binding protein (G protein), gamma 5 subunit

NP_034448.2

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010318.2 → NP_034448.2 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

See identical proteins and their annotated locations for NP_034448.2

Status: VALIDATED

Source sequence(s)

AK146065, BY132164

Consensus CDS

CCDS17903.1

UniProtKB/Swiss-Prot

Q5I0W4, Q80SZ7

UniProtKB/TrEMBL

A0A3B2WD42, Q3UKC8

Related

ENSMUSP00000087485.6, ENSMUST00000090031.12

Conserved Domains (1) summary

cd00068
Location:7 → 63

GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors