Slc38a9 solute carrier family 38, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a9provided by MGI
Official Full Name: solute carrier family 38, member 9provided by MGI
Primary source: MGI:MGI:1918839
See related: Ensembl:ENSMUSG00000047789 AllianceGenome:MGI:1918839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A730092C09; 4833412L08Rik; 6720411P22Rik; 9130023D20Rik; 9430067K09Rik
Summary: Predicted to enable several functions, including L-amino acid transmembrane transporter activity; arginine binding activity; and cholesterol binding activity. Predicted to be involved in carboxylic acid transport; cellular response to amino acid stimulus; and positive regulation of TORC1 signaling. Predicted to be located in late endosome and lysosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human SLC38A9 (solute carrier family 38 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 7.7), thymus adult (RPKM 4.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (112792723..112875286)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (112656189..112738752)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
Title: Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells.
Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins.
Title: mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain.
Title: The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Mit261 (e-PCR), detects polymorphism
- UniSTS:127078

AI848218 (e-PCR)
- UniSTS:180603

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-asparagine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-asparagine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-glutamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-leucine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables arginine binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sterol sensor activity	ISO Inferred from Sequence Orthology more info
enables sterol sensor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in asparagine transport	ISO Inferred from Sequence Orthology more info
involved_in asparagine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in branched-chain amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in glutamine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	IEA Inferred from Electronic Annotation more info
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neutral amino acid transporter 9

Names: putative sodium-coupled neutral amino acid transporter 9; sodium-coupled neutral amino acid transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178746.4 → NP_848861.1 neutral amino acid transporter 9

See identical proteins and their annotated locations for NP_848861.1

Status: VALIDATED

Source sequence(s)

AC159242, AK044735, BC052361

Consensus CDS

CCDS26775.1

UniProtKB/Swiss-Prot

Q80W70, Q8BGD6, Q8C5C3

Related

ENSMUSP00000052172.5, ENSMUST00000052514.6

Conserved Domains (1) summary

cl00456
Location:114 → 556

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

112792723..112875286

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247276.1 → XP_030103136.1 neutral amino acid transporter 9 isoform X1

UniProtKB/Swiss-Prot

Q80W70, Q8BGD6, Q8C5C3

Conserved Domains (1) summary

cl00456
Location:114 → 556

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006517670.4 → XP_006517733.1 neutral amino acid transporter 9 isoform X1

See identical proteins and their annotated locations for XP_006517733.1

UniProtKB/Swiss-Prot

Q80W70, Q8BGD6, Q8C5C3

Conserved Domains (1) summary

cl00456
Location:114 → 556

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006517671.5 → XP_006517734.1 neutral amino acid transporter 9 isoform X2

See identical proteins and their annotated locations for XP_006517734.1

Conserved Domains (1) summary

cl00456
Location:107 → 549

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006517673.5 → XP_006517736.1 neutral amino acid transporter 9 isoform X3

See identical proteins and their annotated locations for XP_006517736.1

Conserved Domains (1) summary

cl00456
Location:52 → 494

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_017315519.3 → XP_017171008.1 neutral amino acid transporter 9 isoform X3

Conserved Domains (1) summary

cl00456
Location:52 → 494

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_036158054.1 → XP_036013947.1 neutral amino acid transporter 9 isoform X4

Conserved Domains (1) summary

cl00456
Location:37 → 289

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006517672.3 → XP_006517735.1 neutral amino acid transporter 9 isoform X2

See identical proteins and their annotated locations for XP_006517735.1

Conserved Domains (1) summary

cl00456
Location:107 → 549

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006517675.4 → XP_006517738.1 neutral amino acid transporter 9 isoform X3

See identical proteins and their annotated locations for XP_006517738.1

Conserved Domains (1) summary

cl00456
Location:52 → 494

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain