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    Comt catechol-O-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 12846, updated on 27-Nov-2024

    Summary

    Official Symbol
    Comtprovided by MGI
    Official Full Name
    catechol-O-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:88470
    See related
    Ensembl:ENSMUSG00000000326 AllianceGenome:MGI:88470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Comt1; D16Wsu103e; D330014B15Rik
    Summary
    Enables catechol O-methyltransferase activity. Acts upstream of or within several processes, including catecholamine metabolic process; learning or memory; and signal release. Located in mitochondrion. Is active in cytosol and vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 254.4), subcutaneous fat pad adult (RPKM 175.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Comt in Genome Data Viewer
    Location:
    16 A3; 16 11.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18225632..18247006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18406882..18426716, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E1921 Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene STARR-positive B cell enhancer ABC_E10891 Neighboring gene microRNA 185 Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene predicted gene 15764 Neighboring gene thioredoxin reductase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18460133-18460376 Neighboring gene STARR-seq mESC enhancer starr_40284 Neighboring gene STARR-seq mESC enhancer starr_40285 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene VISTA enhancer mm321 Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • D330014B15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catechol O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables catechol O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catechol O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within artery development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in catecholamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in catecholamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within catecholamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dopamine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dopamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in estrogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within learning or memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mastication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within norepinephrine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within norepinephrine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of homocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostaglandin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within renal albumin absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within renal filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within renal sodium excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within renin secretion into blood stream IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to corticosterone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to cytokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to external stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to food IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to methylphenidate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to salt IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    catechol O-methyltransferase
    Names
    catechol-O-methyltransferase 1
    NP_001104532.1
    NP_001104533.1
    NP_031770.2
    XP_036015657.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111062.1NP_001104532.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_001104532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC133487, AK148311, AW908224, CX237493
      Consensus CDS
      CCDS28021.1
      UniProtKB/Swiss-Prot
      O88587, Q91XH4
      Related
      ENSMUSP00000000335.5, ENSMUST00000000335.12
      Conserved Domains (1) summary
      cl17173
      Location:60227
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001111063.1NP_001104533.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_001104533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AA250343, AC133487, AK148311, AW908224, GU324998
      Consensus CDS
      CCDS28021.1
      UniProtKB/Swiss-Prot
      O88587, Q91XH4
      Related
      ENSMUSP00000130077.2, ENSMUST00000165430.8
      Conserved Domains (1) summary
      cl17173
      Location:60227
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_007744.3NP_031770.2  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_031770.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC133487, AK148311, AW908224, CX237493
      Consensus CDS
      CCDS28021.1
      UniProtKB/Swiss-Prot
      O88587, Q91XH4
      Related
      ENSMUSP00000111272.3, ENSMUST00000115609.10
      Conserved Domains (1) summary
      cl17173
      Location:60227
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18225632..18247006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159764.1XP_036015657.1  catechol O-methyltransferase isoform X1

      Conserved Domains (1) summary
      COG4122
      Location:5146
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]