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    Il17a interleukin 17A [ Mus musculus (house mouse) ]

    Gene ID: 16171, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il17aprovided by MGI
    Official Full Name
    interleukin 17Aprovided by MGI
    Primary source
    MGI:MGI:107364
    See related
    Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il17; Ctla8; IL-17; Ctla-8; IL-17A
    Summary
    This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Il17a in Genome Data Viewer
    Location:
    1 A4; 1 6.45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (20801129..20804720)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (20730905..20734496)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA of muscle differentiation 1 Neighboring gene microRNA 206 Neighboring gene microRNA 133b Neighboring gene STARR-seq mESC enhancer starr_00390 Neighboring gene interleukin 17F Neighboring gene STARR-positive B cell enhancer ABC_E1536 Neighboring gene minichromosome maintenance complex component 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in granulocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-17-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-17-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-17A-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-17A-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal epithelial structure maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of antimicrobial peptide production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-16 production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of interleukin-16 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-23 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-17A
    Names
    cytotoxic T-lymphocyte-associated antigen 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010552.3NP_034682.1  interleukin-17A precursor

      See identical proteins and their annotated locations for NP_034682.1

      Status: REVIEWED

      Source sequence(s)
      AK040420
      Consensus CDS
      CCDS14842.1
      UniProtKB/Swiss-Prot
      Q60971, Q62386
      UniProtKB/TrEMBL
      Q544E6
      Related
      ENSMUSP00000027061.5, ENSMUST00000027061.5
      Conserved Domains (1) summary
      pfam06083
      Location:72150
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      20801129..20804720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)