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    Lig1 ligase I, DNA, ATP-dependent [ Mus musculus (house mouse) ]

    Gene ID: 16881, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lig1provided by MGI
    Official Full Name
    ligase I, DNA, ATP-dependentprovided by MGI
    Primary source
    MGI:MGI:101789
    See related
    Ensembl:ENSMUSG00000056394 AllianceGenome:MGI:101789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LigI
    Summary
    Predicted to enable DNA ligase (ATP) activity. Acts upstream of or within DNA replication; double-strand break repair via nonhomologous end joining; and response to hydrogen peroxide. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 34.7), liver E14.5 (RPKM 31.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Lig1 in Genome Data Viewer
    Location:
    7 A1; 7 7.82 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13011101..13045351)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13277175..13311426)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 89 Neighboring gene STARR-seq mESC enhancer starr_18077 Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E4896 Neighboring gene STARR-seq mESC enhancer starr_18078 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    NOT acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Okazaki fragment processing involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA ligase 1
    Names
    DNA ligase I
    polydeoxyribonucleotide synthase [ATP] 1
    NP_001076657.2
    NP_001186239.2
    NP_034845.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083188.2NP_001076657.2  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000126525.4, ENSMUST00000165964.10
      Conserved Domains (1) summary
      PLN03113
      Location:171912
      PLN03113; DNA ligase 1; Provisional
    2. NM_001199310.2NP_001186239.2  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000136972.4, ENSMUST00000177588.10
      Conserved Domains (1) summary
      PLN03113
      Location:171912
      PLN03113; DNA ligase 1; Provisional
    3. NM_010715.3NP_034845.3  DNA ligase 1

      Status: VALIDATED

      Source sequence(s)
      AC161792, AK161793, MG954305
      UniProtKB/Swiss-Prot
      P37913
      UniProtKB/TrEMBL
      Q8R055
      Related
      ENSMUSP00000096411.7, ENSMUST00000098814.13
      Conserved Domains (1) summary
      PLN03113
      Location:171912
      PLN03113; DNA ligase 1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      13011101..13045351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)