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    Ccne1 cyclin E1 [ Mus musculus (house mouse) ]

    Gene ID: 12447, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ccne1provided by MGI
    Official Full Name
    cyclin E1provided by MGI
    Primary source
    MGI:MGI:88316
    See related
    Ensembl:ENSMUSG00000002068 AllianceGenome:MGI:88316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycE1
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA replication initiation; chromosome organization; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including aorta-gonad-mesonephros; brain; early conceptus; embryo ectoderm; and eye. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 46.5), liver E14.5 (RPKM 42.0) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Ccne1 in Genome Data Viewer
    Location:
    7 B3; 7 25.35 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (37797409..37806915, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (38097984..38107490, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8166 Neighboring gene URI1, prefoldin-like chaperone Neighboring gene STARR-positive B cell enhancer ABC_E6537 Neighboring gene STARR-seq mESC enhancer starr_18677 Neighboring gene predicted gene, 30684 Neighboring gene predicted gene, 30771 Neighboring gene STARR-positive B cell enhancer ABC_E8167 Neighboring gene STARR-positive B cell enhancer ABC_E4920 Neighboring gene predicted gene, 30912 Neighboring gene STARR-seq mESC enhancer starr_18684 Neighboring gene predicted gene, 22203

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mesenchymal stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesenchymal stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin E1-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin E1-CDK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cyclin E1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007633.2NP_031659.2  G1/S-specific cyclin-E1

      See identical proteins and their annotated locations for NP_031659.2

      Status: VALIDATED

      Source sequence(s)
      BC106191
      Consensus CDS
      CCDS39914.1
      UniProtKB/Swiss-Prot
      Q05BA1, Q05BA6, Q05BB7, Q61457
      UniProtKB/TrEMBL
      B2RS11
      Related
      ENSMUSP00000103658.4, ENSMUST00000108023.10
      Conserved Domains (2) summary
      pfam00134
      Location:113240
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:243362
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      37797409..37806915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)