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    Tert telomerase reverse transcriptase [ Mus musculus (house mouse) ]

    Gene ID: 21752, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tertprovided by MGI
    Official Full Name
    telomerase reverse transcriptaseprovided by MGI
    Primary source
    MGI:MGI:1202709
    See related
    Ensembl:ENSMUSG00000021611 AllianceGenome:MGI:1202709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TR; TP2; TRT; EST2; TCS1
    Summary
    Enables telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of D-glucose import. Located in mitochondrion and plasma membrane. Part of telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 4.7), adrenal adult (RPKM 3.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tert in Genome Data Viewer
    Location:
    13 C1; 13 40.12 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73775030..73797962)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73626911..73649843)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Neighboring gene CLPTM1-like Neighboring gene Tert 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_34994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:73778847-73779048 Neighboring gene STARR-seq mESC enhancer starr_34995 Neighboring gene STARR-seq mESC enhancer starr_34996 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 18 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC150124

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA-dependent RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA-dependent RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables template-free RNA nucleotidyltransferase IEA
    Inferred from Electronic Annotation
    more info
     
    enables template-free RNA nucleotidyltransferase ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA strand elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA-templated DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to telomere IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hair cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transdifferentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transdifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replicative senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replicative senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in siRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in siRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in siRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in siRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via recombination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance via telomerase ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere maintenance via telomerase NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in telomere maintenance via telomerase TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA-directed RNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TERT-RMRP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TERT-RMRP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of telomerase catalytic core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of telomerase catalytic core complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of telomerase catalytic core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase catalytic core complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of telomerase holoenzyme complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    telomerase reverse transcriptase
    Names
    telomerase catalytic subunit
    telomerase reverse transcriptase beta
    NP_001349316.1
    NP_001349317.1
    NP_033380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362387.1NP_001349316.1  telomerase reverse transcriptase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158359, AK133783, BC082327
      Conserved Domains (2) summary
      smart00975
      Location:57191
      Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
      cd01648
      Location:422536
      TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
    2. NM_001362388.1NP_001349317.1  telomerase reverse transcriptase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK133783, BC082327, BC127068
      UniProtKB/TrEMBL
      A0JNY9
      Conserved Domains (2) summary
      cd01648
      Location:277391
      TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
      cl13446
      Location:146
      Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
    3. NM_009354.2NP_033380.1  telomerase reverse transcriptase isoform 1

      See identical proteins and their annotated locations for NP_033380.1

      Status: VALIDATED

      Source sequence(s)
      AF051911, AK133783, BC082327
      Consensus CDS
      CCDS26633.1
      UniProtKB/Swiss-Prot
      O35432, O70372, Q9JK99
      Related
      ENSMUSP00000022104.8, ENSMUST00000022104.9
      Conserved Domains (2) summary
      smart00975
      Location:450584
      Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
      cd01648
      Location:815929
      TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      73775030..73797962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)