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    Zfp426 zinc finger protein 426 [ Mus musculus (house mouse) ]

    Gene ID: 235028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp426provided by MGI
    Official Full Name
    zinc finger protein 426provided by MGI
    Primary source
    MGI:MGI:1920248
    See related
    Ensembl:ENSMUSG00000059475 AllianceGenome:MGI:1920248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB1; Zfo61; Znf426; Zfp68-rs1; mKIAA4237; 2900057C04Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; reproductive system; and urinary system. Orthologous to human ZNF426 (zinc finger protein 426). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.3), CNS E18 (RPKM 3.2) and 26 other tissues See more
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    Genomic context

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    See Zfp426 in Genome Data Viewer
    Location:
    9 A3; 9 7.55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20379845..20404042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20468549..20492746, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 560 Neighboring gene STARR-positive B cell enhancer ABC_E9752 Neighboring gene zinc finger protein 26 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene predicted gene, 23316 Neighboring gene zinc finger protein 266 Neighboring gene predicted gene, 46142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • KIAA4237, MGC38791

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 426
    Names
    zinc finger protein 68, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110309.1 → NP_001103779.1  zinc finger protein 426 isoform 1

      See identical proteins and their annotated locations for NP_001103779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AK085144, BC024805
      Consensus CDS
      CCDS40544.1
      UniProtKB/Swiss-Prot
      Q5DTF7, Q8BJ29, Q8CIG1, Q8R1D1
      Related
      ENSMUSP00000079250.7, ENSMUST00000080386.13
      Conserved Domains (6) summary
      smart00349
      Location:39 → 96
      KRAB; krueppel associated box
      COG5048
      Location:328 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:444 → 464
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:219 → 241
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:39 → 78
      KRAB; KRAB box
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001310742.1 → NP_001297671.1  zinc finger protein 426 isoform 2

      See identical proteins and their annotated locations for NP_001297671.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splice sites in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK085144, BC024805, CN725012
      Consensus CDS
      CCDS80962.1
      UniProtKB/TrEMBL
      G5E8Y1
      Related
      ENSMUSP00000126446.2, ENSMUST00000163348.8
      Conserved Domains (6) summary
      smart00349
      Location:39 → 96
      KRAB; krueppel associated box
      COG5048
      Location:327 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:218 → 240
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:39 → 78
      KRAB; KRAB box
      pfam13465
      Location:455 → 480
      zf-H2C2_2; Zinc-finger double domain

    3. NM_146221.4 → NP_666333.1  zinc finger protein 426 isoform 1

      See identical proteins and their annotated locations for NP_666333.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK085144
      Consensus CDS
      CCDS40544.1
      UniProtKB/Swiss-Prot
      Q5DTF7, Q8BJ29, Q8CIG1, Q8R1D1
      Related
      ENSMUSP00000111224.3, ENSMUST00000115562.9
      Conserved Domains (6) summary
      smart00349
      Location:39 → 96
      KRAB; krueppel associated box
      COG5048
      Location:328 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:444 → 464
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:219 → 241
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:39 → 78
      KRAB; KRAB box
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20379845..20404042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1D1.1 GenPept UniProtKB/Swiss-Prot:Q8R1D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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