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    Cotl1 coactosin like F-actin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 72042, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cotl1provided by MGI
    Official Full Name
    coactosin like F-actin binding protein 1provided by MGI
    Primary source
    MGI:MGI:1919292
    See related
    Ensembl:ENSMUSG00000031827 AllianceGenome:MGI:1919292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clp; 1810074P22Rik; 2010004C08Rik
    Summary
    Enables actin binding activity and enzyme binding activity. Involved in defense response to fungus. Predicted to be located in cytosol. Predicted to be active in cortical actin cytoskeleton and site of polarized growth. Predicted to colocalize with actin filament. Is expressed in several structures, including brain; gut; renal cortex; sensory organ; and trachea. Orthologous to human COTL1 (coactosin like F-actin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach adult (RPKM 370.0), spleen adult (RPKM 262.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Cotl1 in Genome Data Viewer
    Location:
    8 E1; 8 68.42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120535953..120567318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119809214..119840579, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, Ca++ transporting, type 2C, member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122241776-122242076 Neighboring gene STARR-positive B cell enhancer ABC_E113 Neighboring gene MTOR associated protein, eak-7 homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122361795-122361952 Neighboring gene STARR-positive B cell enhancer ABC_E2880 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122367394-122367695 Neighboring gene STARR-positive B cell enhancer ABC_E2881 Neighboring gene kelch-like 36 Neighboring gene predicted gene, 53464

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response to fungus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    coactosin-like protein
    Names
    coactosin-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028071.3NP_082347.1  coactosin-like protein

      See identical proteins and their annotated locations for NP_082347.1

      Status: VALIDATED

      Source sequence(s)
      AK151690, AK196452, BY200873
      Consensus CDS
      CCDS22712.1
      UniProtKB/Swiss-Prot
      Q9CQI6
      UniProtKB/TrEMBL
      Q544F6
      Related
      ENSMUSP00000034285.7, ENSMUST00000034285.14
      Conserved Domains (1) summary
      cd11282
      Location:9120
      ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120535953..120567318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)