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    METTL25B methyltransferase like 25B [ Homo sapiens (human) ]

    Gene ID: 51093, updated on 3-Dec-2024

    Summary

    Official Symbol
    METTL25Bprovided by HGNC
    Official Full Name
    methyltransferase like 25Bprovided by HGNC
    Primary source
    HGNC:HGNC:24273
    See related
    Ensembl:ENSG00000143303 AllianceGenome:HGNC:24273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-41; RRNAD1; C1orf66
    Summary
    Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.0), prostate (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See METTL25B in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156728469..156736960)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155864872..155873793)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156698261..156706752)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156642834-156643494 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156643495-156644156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156645479-156646139 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156646801-156647461 Neighboring gene nestin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156661895-156662812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    methyltransferase-like protein 25B
    Names
    protein RRNAD1
    ribosomal RNA adenine dimethylase domain containing 1
    ribosomal RNA adenine dimethylase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142560.2NP_001136032.1  methyltransferase-like protein 25B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590666, BX094595
      Consensus CDS
      CCDS44246.1
      UniProtKB/Swiss-Prot
      Q96FB5
      Related
      ENSP00000357201.4, ENST00000368218.8
      Conserved Domains (1) summary
      cl17173
      Location:133221
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_015997.4NP_057081.3  methyltransferase-like protein 25B isoform 1

      See identical proteins and their annotated locations for NP_057081.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL590666, BX094595
      Consensus CDS
      CCDS1154.1
      UniProtKB/Swiss-Prot
      D3DVC7, Q4VX71, Q5SZ03, Q96FB5, Q9Y358
      Related
      ENSP00000357199.4, ENST00000368216.9
      Conserved Domains (1) summary
      pfam13679
      Location:133293
      Methyltransf_32; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156728469..156736960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245234.6XP_005245291.1  methyltransferase-like protein 25B isoform X1

      Conserved Domains (1) summary
      pfam13679
      Location:133293
      Methyltransf_32; Methyltransferase domain
    2. XM_024447421.2XP_024303189.1  methyltransferase-like protein 25B isoform X9

      Conserved Domains (1) summary
      cl17173
      Location:133224
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_005245236.6XP_005245293.1  methyltransferase-like protein 25B isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:133222
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_005245237.6XP_005245294.1  methyltransferase-like protein 25B isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:133221
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_005245235.6XP_005245292.1  methyltransferase-like protein 25B isoform X3

      Conserved Domains (1) summary
      pfam13679
      Location:63223
      Methyltransf_32; Methyltransferase domain
    6. XM_047421948.1XP_047277904.1  methyltransferase-like protein 25B isoform X10

    7. XM_011509600.2XP_011507902.1  methyltransferase-like protein 25B isoform X2

      Conserved Domains (1) summary
      pfam13679
      Location:67227
      Methyltransf_32; Methyltransferase domain
    8. XM_047421932.1XP_047277888.1  methyltransferase-like protein 25B isoform X4

      UniProtKB/TrEMBL
      E5RHI7
      Related
      ENSP00000429756.1, ENST00000519086.5
    9. XM_047421937.1XP_047277893.1  methyltransferase-like protein 25B isoform X5

    10. XM_047421943.1XP_047277899.1  methyltransferase-like protein 25B isoform X8

    11. XM_047421944.1XP_047277900.1  methyltransferase-like protein 25B isoform X8

    12. XM_017001404.2XP_016856893.1  methyltransferase-like protein 25B isoform X2

      Conserved Domains (1) summary
      pfam13679
      Location:67227
      Methyltransf_32; Methyltransferase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155864872..155873793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336874.1XP_054192849.1  methyltransferase-like protein 25B isoform X6

    2. XM_054336871.1XP_054192846.1  methyltransferase-like protein 25B isoform X3

    3. XM_054336879.1XP_054192854.1  methyltransferase-like protein 25B isoform X10

    4. XM_054336869.1XP_054192844.1  methyltransferase-like protein 25B isoform X1

    5. XM_054336878.1XP_054192853.1  methyltransferase-like protein 25B isoform X9

    6. XM_054336875.1XP_054192850.1  methyltransferase-like protein 25B isoform X7

    7. XM_054336872.1XP_054192847.1  methyltransferase-like protein 25B isoform X4

      UniProtKB/TrEMBL
      E5RHI7
    8. XM_054336876.1XP_054192851.1  methyltransferase-like protein 25B isoform X8

    9. XM_054336877.1XP_054192852.1  methyltransferase-like protein 25B isoform X8

    10. XM_054336870.1XP_054192845.1  methyltransferase-like protein 25B isoform X2

    11. XM_054336873.1XP_054192848.1  methyltransferase-like protein 25B isoform X5