Ms4a4a membrane spanning 4-domains A4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ms4a4aprovided by RGD
Full Name: membrane spanning 4-domains A4Aprovided by RGD
Primary source: RGD:1307006
See related: EnsemblRapid:ENSRNOG00000050024 AllianceGenome:RGD:1307006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ms4a4e
Summary: Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane raft. Orthologous to several human genes including MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 82.6), Thymus (RPKM 74.4) and 7 other tissues See more
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Genomic context

Location:: 1q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (217495704..217510019)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (208060507..208085121)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (227574789..227606958)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane-spanning 4-domains subfamily A member 4A

Names: membrane spanning 4-domains A4E; membrane-spanning 4-domains subfamily A member 4A-like; membrane-spanning 4-domains, subfamily A, member 4; membrane-spanning 4-domains, subfamily A, member 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432333.1 → NP_001419262.1 membrane-spanning 4-domains subfamily A member 4A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

M0R3W2, M0R824
NM_001432334.1 → NP_001419263.1 membrane-spanning 4-domains subfamily A member 4A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RNA

NR_197280.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

217495704..217510019

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101346.2 → XP_038957274.1 membrane-spanning 4-domains subfamily A member 4A isoform X1

Related

ENSRNOP00000064035.2, ENSRNOT00000072135.4

Conserved Domains (1) summary

pfam04103
Location:46 → 188

CD20; CD20-like family
XM_008760275.4 → XP_008758497.1 membrane-spanning 4-domains subfamily A member 4A isoform X2

Conserved Domains (1) summary

pfam04103
Location:49 → 145

CD20; CD20-like family