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    Mmp27 matrix metallopeptidase 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300340, updated on 27-Dec-2024

    Summary

    Official Symbol
    Mmp27provided by RGD
    Official Full Name
    matrix metallopeptidase 27provided by RGD
    Primary source
    RGD:1306642
    See related
    EnsemblRapid:ENSRNOG00000040208 AllianceGenome:RGD:1306642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in endoplasmic reticulum. Orthologous to human MMP27 (matrix metallopeptidase 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 6.4), Uterus (RPKM 0.8) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Mmp27 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (13030752..13040671)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4745887..4755806)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (5790019..5799938)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 10 Neighboring gene matrix metallopeptidase 8 Neighboring gene matrix metallopeptidase 20 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-27
    Names
    matrix metalloproteinase 27

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106799.1NP_001100269.1  matrix metalloproteinase-27 precursor

      See identical proteins and their annotated locations for NP_001100269.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473993
      UniProtKB/TrEMBL
      A6JN37, D3ZQ07
      Related
      ENSRNOP00000058603.3, ENSRNOT00000061887.5
      Conserved Domains (4) summary
      cd00094
      Location:277466
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:106262
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:106262
      Peptidase_M10; Matrixin
      pfam01471
      Location:3186
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      13030752..13040671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)