Tymp thymidine phosphorylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tympprovided by RGD
Official Full Name: thymidine phosphorylaseprovided by RGD
Primary source: RGD:1305756
See related: EnsemblRapid:ENSRNOG00000032394 AllianceGenome:RGD:1305756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TP; Ecgf1
Summary: Predicted to enable protein homodimerization activity and thymidine phosphorylase activity. Predicted to be involved in several processes, including dTMP catabolic process; regulation of gastric motility; and regulation of myelination. Predicted to be located in mitochondrial inner membrane and myofibril. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 519.2), Thymus (RPKM 105.8) and 9 other tissues See more
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Genomic context

Location:: 7q34

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122318396..122323716, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120438768..120444088, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130342481..130347845, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PyNpase levels in rat bladder tissue were significantly higher in the BBN-treatment groups than in those in the control group, only during the early carcinogenic stage
Title: Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139883 (e-PCR)
- UniSTS:221967

RH128722 (e-PCR)
- UniSTS:212030

Tymp (e-PCR), detects polymorphism
- UniSTS:547168

RH136025 (e-PCR)
- UniSTS:210021

RH129073 (e-PCR)
- UniSTS:212381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info
enables thymidine phosphorylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dTMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in eye development	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial cytochrome c oxidase assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in muscle system process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleoside metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in myofibril	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymidine phosphorylase

Names: endothelial cell growth factor 1 (platelet-derived); tdRPase

NP_001012122.1

EC 2.4.2.4

XP_006242271.1

EC 2.4.2.4

XP_008763952.1

EC 2.4.2.4

XP_038935237.1

EC 2.4.2.4

XP_038935238.1

EC 2.4.2.4

XP_038935239.1

EC 2.4.2.4

XP_038935241.1

EC 2.4.2.4

XP_063119723.1

EC 2.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012122.2 → NP_001012122.1 thymidine phosphorylase

See identical proteins and their annotated locations for NP_001012122.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q5FVR2

UniProtKB/TrEMBL

A6K7M1

Conserved Domains (4) summary

smart00941
Location:381 → 455

PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain

TIGR02644
Location:30 → 439

Y_phosphoryl; pyrimidine-nucleoside phosphorylase

pfam00591
Location:103 → 333

Glycos_transf_3; Glycosyl transferase family, a/b domain

pfam02885
Location:31 → 91

Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122318396..122323716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079310.2 → XP_038935238.1 thymidine phosphorylase isoform X4

Related

ENSRNOP00000039935.4, ENSRNOT00000040541.6

Conserved Domains (2) summary

cd02968
Location:592 → 733

SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

cl29556
Location:30 → 380

Glycos_transf_3; Glycosyl transferase family, a/b domain
XM_006242209.5 → XP_006242271.1 thymidine phosphorylase isoform X3

Conserved Domains (4) summary

COG0547
Location:28 → 343

TrpD; Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]

cd02968
Location:593 → 734

SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

pfam00591
Location:103 → 334

Glycos_transf_3; Glycosyl transferase family, a/b domain

pfam02885
Location:31 → 91

Glycos_trans_3N; Glycosyl transferase family, helical bundle domain
XM_039079309.2 → XP_038935237.1 thymidine phosphorylase isoform X2

Conserved Domains (2) summary

cd02968
Location:594 → 735

SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

cl29556
Location:30 → 382

Glycos_transf_3; Glycosyl transferase family, a/b domain
XM_008765730.4 → XP_008763952.1 thymidine phosphorylase isoform X1

Conserved Domains (4) summary

COG0547
Location:28 → 345

TrpD; Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]

cd02968
Location:595 → 736

SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

pfam00591
Location:103 → 336

Glycos_transf_3; Glycosyl transferase family, a/b domain

pfam02885
Location:31 → 91

Glycos_trans_3N; Glycosyl transferase family, helical bundle domain
XM_039079311.2 → XP_038935239.1 thymidine phosphorylase isoform X5

Conserved Domains (2) summary

cd02968
Location:341 → 482

SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...

cl29556
Location:2 → 129

Glycos_transf_3; Glycosyl transferase family, a/b domain
XM_039079313.2 → XP_038935241.1 thymidine phosphorylase isoform X7

Conserved Domains (1) summary

cl40719
Location:30 → 442

PRK06078; pyrimidine-nucleoside phosphorylase; Reviewed
XM_063263653.1 → XP_063119723.1 thymidine phosphorylase isoform X6