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    Lars2 leucyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lars2provided by RGD
    Official Full Name
    leucyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1308429
    See related
    EnsemblRapid:ENSRNOG00000004760 AllianceGenome:RGD:1308429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 101.9), Muscle (RPKM 83.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lars2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131887728..131983866)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123010271..123106395)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132441277..132537176)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480117 Neighboring gene transmembrane protein 158 Neighboring gene LIM domain containing 1 Neighboring gene uncharacterized LOC134480118 Neighboring gene transfer RNA arginine (anticodon ACG) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. Riley LG, et al. JIMD Rep, 2016. PMID 26537577, Free PMC Article
    2. Expression and characterization of the human mitochondrial leucyl-tRNA synthetase. Bullard JM, et al. Biochim Biophys Acta, 2000 Feb 29. PMID 10684970
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine--tRNA ligase, mitochondrial
    Names
    leucyl-tRNA synthetase, mitochondrial
    probable leucine--tRNA ligase, mitochondrial
    probable leucyl-tRNA synthetase, mitochondrial
    NP_001400771.1
    XP_008764949.1
    XP_063121930.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413842.1 → NP_001400771.1  leucine--tRNA ligase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZU78
      Related
      ENSRNOP00000082486.1, ENSRNOT00000101297.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      131887728..131983866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265860.1 → XP_063121930.1  leucine--tRNA ligase, mitochondrial isoform X2

    2. XM_008766727.4 → XP_008764949.1  leucine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K9E5, A0A8I6G2M3
      Related
      ENSRNOP00000074967.2, ENSRNOT00000087488.3
      Conserved Domains (4) summary
      cd07958
      Location:626 → 751
      Anticodon_Ia_Leu_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases
      cd00812
      Location:82 → 626
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PRK00390
      Location:56 → 850
      leuS; leucyl-tRNA synthetase; Validated
      pfam13603
      Location:219 → 378
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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