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    Krt83 keratin 83 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt83provided by RGD
    Official Full Name
    keratin 83provided by RGD
    Primary source
    RGD:1303024
    See related
    EnsemblRapid:ENSRNOG00000030814 AllianceGenome:RGD:1303024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kb23
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair cycle; intermediate filament organization; and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 30.5) See more
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    Genomic context

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    See Krt83 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134482911..134489600, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132604180..132610869, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143134980..143141659, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 81 Neighboring gene keratin 86 Neighboring gene keratin 85 Neighboring gene keratin 84

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Nanashima N, et al. J Biol Chem, 2008 Jun 13. PMID 18420582
    2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament-based process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type II keratin 23
    Names
    type II keratin Kb23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389278.1 → NP_001376207.1  type II keratin 23

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AFC7, A7M776, D3ZWS9
      Related
      ENSRNOP00000059981.3, ENSRNOT00000068505.5
      Conserved Domains (2) summary
      pfam00038
      Location:103 → 414
      Filament; Intermediate filament protein
      pfam16208
      Location:4 → 100
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134482911..134489600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079712.2 → XP_038935640.2  type II keratin 23 isoform X1

      UniProtKB/TrEMBL
      Q6IG08
      Related
      ENSRNOP00000075208.3, ENSRNOT00000077207.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008813.1: Suppressed sequence

      Description
      NM_001008813.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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