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    Adgrb3 adhesion G protein-coupled receptor B3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301309, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Adgrb3provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor B3provided by RGD
    Primary source
    RGD:1309703
    See related
    EnsemblRapid:ENSRNOG00000012045 AllianceGenome:RGD:1309703
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bai3
    Summary
    Predicted to enable G protein-coupled receptor activity and GTPase activator activity. Predicted to be involved in several processes, including myoblast fusion; neuron remodeling; and regulation of synapse organization. Predicted to act upstream of or within maintenance of synapse structure; motor learning; and positive regulation of synapse assembly. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse; postsynaptic density membrane; and synaptic cleft. Orthologous to human ADGRB3 (adhesion G protein-coupled receptor B3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 198.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrb3 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (34917474..35645350, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (27421168..28148979, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (31280623..32022535, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480282 Neighboring gene proteasome activator subunit 1, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120094653 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons. Lanoue V, et al. Mol Psychiatry, 2013 Aug. PMID 23628982, Free PMC Article
    2. Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. Kakegawa W, et al. Neuron, 2015 Jan 21. PMID 25611509
    3. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. Hamoud N, et al. Proc Natl Acad Sci U S A, 2014 Mar 11. PMID 24567399, Free PMC Article
    4. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Bolliger MF, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21262840, Free PMC Article
    5. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within maintenance of synapse structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motor learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse pruning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cerebellar climbing fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic cleft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor B3
    Names
    brain-specific angiogenesis inhibitor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106898.1 → NP_001100368.1  adhesion G protein-coupled receptor B3

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A6JJC3, D4A831
      Related
      ENSRNOP00000016194.4, ENSRNOT00000016194.6
      Conserved Domains (5) summary
      smart00303
      Location:816 → 867
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:510 → 576
      HormR; Domain present in hormone receptors
      smart00209
      Location:348 → 398
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:876 → 1143
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:595 → 792
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      34917474..35645350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266875.1 → XP_063122945.1  adhesion G protein-coupled receptor B3 isoform X6

    2. XM_063266874.1 → XP_063122944.1  adhesion G protein-coupled receptor B3 isoform X5

    3. XM_039083196.2 → XP_038939124.1  adhesion G protein-coupled receptor B3 isoform X4

      Related
      ENSRNOP00000100806.1, ENSRNOT00000135240.1
      Conserved Domains (6) summary
      smart00303
      Location:779 → 830
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:473 → 539
      HormR; Domain present in hormone receptors
      smart00209
      Location:311 → 361
      TSP1; Thrombospondin type 1 repeats
      cd15989
      Location:835 → 1127
      7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:557 → 757
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      pfam19188
      Location:29 → 203
      AGRB_N; Adhesion GPCR B N-terminal region

    4. XM_017596334.3 → XP_017451823.1  adhesion G protein-coupled receptor B3 isoform X2

      Related
      ENSRNOP00000100223.1, ENSRNOT00000125810.1

    5. XM_063266873.1 → XP_063122943.1  adhesion G protein-coupled receptor B3 isoform X1

      Related
      ENSRNOP00000100960.1, ENSRNOT00000149873.1

    6. XM_039083195.2 → XP_038939123.1  adhesion G protein-coupled receptor B3 isoform X3

      Conserved Domains (6) summary
      smart00303
      Location:816 → 867
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:510 → 576
      HormR; Domain present in hormone receptors
      smart00209
      Location:348 → 398
      TSP1; Thrombospondin type 1 repeats
      cd15989
      Location:872 → 1164
      7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:594 → 794
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      pfam19188
      Location:29 → 203
      AGRB_N; Adhesion GPCR B N-terminal region

    7. XM_039083198.2 → XP_038939126.1  adhesion G protein-coupled receptor B3 isoform X7

      Conserved Domains (5) summary
      smart00303
      Location:483 → 534
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:177 → 243
      HormR; Domain present in hormone receptors
      smart00209
      Location:15 → 65
      TSP1; Thrombospondin type 1 repeats
      cd15989
      Location:539 → 831
      7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:261 → 461
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    8. XM_039083197.1 → XP_038939125.1  adhesion G protein-coupled receptor B3 isoform X7

      Conserved Domains (5) summary
      smart00303
      Location:483 → 534
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:177 → 243
      HormR; Domain present in hormone receptors
      smart00209
      Location:15 → 65
      TSP1; Thrombospondin type 1 repeats
      cd15989
      Location:539 → 831
      7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:261 → 461
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    9. XM_039083199.1 → XP_038939127.1  adhesion G protein-coupled receptor B3 isoform X8

      Conserved Domains (3) summary
      smart00303
      Location:228 → 279
      GPS; G-protein-coupled receptor proteolytic site domain
      cd15989
      Location:284 → 576
      7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:6 → 206
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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