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    Cnot8 CCR4-NOT transcription complex, subunit 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363603, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cnot8provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 8provided by RGD
    Primary source
    RGD:1306401
    See related
    EnsemblRapid:ENSRNOG00000002630 AllianceGenome:RGD:1306401
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in miRNA-mediated gene silencing by mRNA destabilization; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 312.9), Spleen (RPKM 240.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cnot8 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42782042..42795207)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42281614..42294740)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43538150..43551271)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene gem (nuclear organelle) associated protein 5 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene interferon gamma induced GTPase like 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Clone Names

    • MGC94581

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 8
    NP_001008383.1
    XP_006246454.1
    XP_038942393.1
    XP_063125577.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008382.1NP_001008383.1  CCR4-NOT transcription complex subunit 8

      See identical proteins and their annotated locations for NP_001008383.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085856
      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42782042..42795207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086465.2XP_038942393.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    2. XM_006246392.5XP_006246454.1  CCR4-NOT transcription complex subunit 8 isoform X1

      See identical proteins and their annotated locations for XP_006246454.1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    3. XM_063269507.1XP_063125577.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/TrEMBL
      A6HEQ7, F7F1V4, Q5U2U9
      Related
      ENSRNOP00000003555.3, ENSRNOT00000003555.6