Itgb8 integrin subunit beta 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgb8provided by RGD
Official Full Name: integrin subunit beta 8provided by RGD
Primary source: RGD:1311374
See related: EnsemblRapid:ENSRNOG00000006569 AllianceGenome:RGD:1311374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables signaling receptor binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; regulation of gene expression; and vasculogenesis. Predicted to act upstream of or within several processes, including Langerhans cell differentiation; hard palate development; and transforming growth factor beta receptor signaling pathway. Predicted to be part of integrin alphav-beta8 complex. Predicted to be active in cell surface and focal adhesion. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 381.8), Brain (RPKM 176.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (146267982..146351245, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (140125002..140208261, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (147089280..147172846, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin beta8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-beta1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Title: Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
miR222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.
Title: miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.
The highly expressed beta8 plays important roles in the regulation of TGF-beta1 activation in neonatal rats with hypoxic-ischemic brain damage.
Title: [Effect of integrin β8 on TGF-β1 activation in astrocytes with oxygen glucose deprivation].

Submit: New GeneRIF Correction

General gene information

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Markers

ITGB8 (e-PCR)
- UniSTS:71013

MARC_23311-23312:1024579300:3 (e-PCR)
- UniSTS:268671

BF386390 (e-PCR)
- UniSTS:243699

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Langerhans cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ganglioside metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hard palate development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alphav-beta8 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: integrin beta-8

Names: integrin, beta 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.