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    Fcar Fc alpha receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365183, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fcarprovided by RGD
    Official Full Name
    Fc alpha receptorprovided by RGD
    Primary source
    RGD:1303082
    See related
    AllianceGenome:RGD:1303082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD89
    Summary
    Predicted to enable IgA binding activity and IgA receptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and positive regulation of neutrophil apoptotic process. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; granulomatosis with polyangiitis; and renal fibrosis. Orthologous to human FCAR (Fc alpha receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 4.4), Spleen (RPKM 3.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fcar in Genome Data Viewer
    Location:
    1q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78669119..78703223, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69626458..69660558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (73230392..73263462, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 4, pseudogene 1 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene thioredoxin domain-containing protein 11-like Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Neighboring gene motile sperm domain containing 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis. Kelley JM, et al. Proc Natl Acad Sci U S A, 2011 Dec 20. PMID 22147912, Free PMC Article
    2. Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. Kanamaru Y, et al. J Immunol, 2008 Feb 15. PMID 18250479
    3. Identification of the rat IgA Fc receptor encoded in the leukocyte receptor complex. Maruoka T, et al. Immunogenetics, 2004 Jan. PMID 14647992
    4. Negative regulation of inflammatory responses by immunoglobulin A receptor (FcαRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis. Watanabe T, et al. Clin Exp Immunol, 2011 Nov. PMID 21985370, Free PMC Article
    5. Transglutaminase is essential for IgA nephropathy development acting through IgA receptors. Berthelot L, et al. J Exp Med, 2012 Apr 9. PMID 22451718, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables IgA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables IgA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin alpha Fc receptor
    Names
    Fc fragment of IgA receptor
    Fc fragment of IgA, receptor for
    IgA Fc receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201992.1 → NP_973721.1  immunoglobulin alpha Fc receptor precursor

      See identical proteins and their annotated locations for NP_973721.1

      Status: PROVISIONAL

      Source sequence(s)
      AB109766
      UniProtKB/TrEMBL
      A6KNK6
      Conserved Domains (1) summary
      cl11960
      Location:122 → 212
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78669119..78703223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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