U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Egfl7 EGF-like-domain, multiple 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245963, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Egfl7provided by RGD
    Official Full Name
    EGF-like-domain, multiple 7provided by RGD
    Primary source
    RGD:708507
    See related
    EnsemblRapid:ENSRNOG00000019388 AllianceGenome:RGD:708507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in vasculogenesis. Predicted to act upstream of or within negative regulation of Notch signaling pathway; negative regulation of smooth muscle cell migration; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular space. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 876.4), Heart (RPKM 373.5) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Egfl7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29802481..29814966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9404622..9416879)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4034759..4044280)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101512 Neighboring gene RNA, U6 small nuclear 198 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene divergent protein kinase domain 1B Neighboring gene uncharacterized LOC100911266 Neighboring gene small nucleolar RNA SNORA43

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway. Xian Y, et al. Life Sci, 2024 Mar 1. PMID 38307238
    2. Astragalus polysaccharides exert protective effects in newborn rats with bronchopulmonary dysplasia by upregulating the expression of EGFL7 in lung tissue. Wang XH, et al. Int J Mol Med, 2014 Dec. PMID 25270395
    3. VE-statin, an endothelial repressor of smooth muscle cell migration. Soncin F, et al. EMBO J, 2003 Nov 3. PMID 14592969, Free PMC Article
    4. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Fitch MJ, et al. Dev Dyn, 2004 Jun. PMID 15162510, Free PMC Article
    5. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Parker LH, et al. Nature, 2004 Apr 15. PMID 15085134

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
      Title: The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
    2. Data show that Astragalus polysaccharides reduce airway remodeling and alveolar damage by upregulating the expression of epidermal growth factor-like domains protein 7 (EGFL7) and exert protective effects against dysplasia in neonatal rats.
      Title: Astragalus polysaccharides exert protective effects in newborn rats with bronchopulmonary dysplasia by upregulating the expression of EGFL7 in lung tissue.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC93163

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    epidermal growth factor-like protein 7
    Names
    EGF-like domain 7
    EGF-like domain-containing protein 7
    EGF-like protein 7
    Estrogen-regulated protein CBL20, 20.4kD
    multiple EGF-like domain protein 7
    multiple EGF-like domains protein 7
    multiple epidermal growth factor-like domain protein 7
    multiple epidermal growth factor-like domains protein 7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399187.1 → NP_001386116.1  epidermal growth factor-like protein 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000026318.6, ENSRNOT00000026318.8
      Conserved Domains (2) summary
      pfam07645
      Location:145 → 184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32 → 101
      EMI; EMI domain

    2. NM_001399188.1 → NP_001386117.1  epidermal growth factor-like protein 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000088876.2, ENSRNOT00000107620.2
      Conserved Domains (2) summary
      pfam07645
      Location:145 → 184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32 → 101
      EMI; EMI domain

    RNA

    1. NR_174164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29802481..29814966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104248.2 → XP_038960176.1  epidermal growth factor-like protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000081631.2, ENSRNOT00000115008.2
      Conserved Domains (2) summary
      pfam07645
      Location:145 → 184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32 → 101
      EMI; EMI domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AZ60.1 GenPept UniProtKB/Swiss-Prot:Q6AZ60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials