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    Chad chondroadherin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29195, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chadprovided by RGD
    Official Full Name
    chondroadherinprovided by RGD
    Primary source
    RGD:2336
    See related
    EnsemblRapid:ENSRNOG00000003304 AllianceGenome:RGD:2336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in cartilage condensation. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CHAD (chondroadherin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 19.9), Muscle (RPKM 18.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chad in Genome Data Viewer
    Location:
    10q26
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80009045..80012816)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79512170..79515941)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82290296..82296146)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Mycbp associated protein Neighboring gene uncharacterized LOC108352211 Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene uncharacterized LOC102555790 Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chondroadherin expression changes in skeletal development. Shen Z, et al. Biochem J, 1998 Feb 15. PMID 9461555, Free PMC Article
    2. The skeletal phenotype of chondroadherin deficient mice. Hessle L, et al. PLoS One, 2014. PMID 23755099, Free PMC Article
    3. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Potter E, et al. Nature, 1991 Jan 31. PMID 1846945
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cartilage condensation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of bone trabecula formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of bone trabecula formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroadherin
    Names
    cartilage leucine-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019164.2 → NP_062037.1  chondroadherin precursor

      See identical proteins and their annotated locations for NP_062037.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O70210
      UniProtKB/TrEMBL
      A0A0H2UHB8, A6HI58
      Related
      ENSRNOP00000004435.3, ENSRNOT00000004435.6
      Conserved Domains (5) summary
      smart00082
      Location:299 → 346
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:89 → 281
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:52 → 75
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01462
      Location:22 → 48
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:74 → 134
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      80009045..80012816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70210.1 GenPept UniProtKB/Swiss-Prot:O70210

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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