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    Tlr11 toll-like receptor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498491, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tlr11provided by RGD
    Official Full Name
    toll-like receptor 11provided by RGD
    Primary source
    RGD:1564460
    See related
    EnsemblRapid:ENSRNOG00000032368 AllianceGenome:RGD:1564460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564460
    Summary
    Predicted to enable signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Spleen (RPKM 49.6), Thymus (RPKM 19.4) and 4 other tissues See more
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    Genomic context

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    See Tlr11 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26018987..26023426)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (23545408..23549849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27177900..27182339)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily M member 1 Neighboring gene olfactory receptor family 4 subfamily Q member 3 Neighboring gene olfactory receptor family 11 subfamily J member 4 Neighboring gene olfactory receptor family 11 subfamily G member 1 Neighboring gene olfactory receptor family 11 subfamily G member 26B Neighboring gene olfactory receptor family 11 subfamily G member 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Palladino MA, et al. Biol Reprod, 2007 Jun. PMID 17314314
    2. A toll-like receptor that prevents infection by uropathogenic bacteria. Zhang D, et al. Science, 2004 Mar 5. PMID 15001781
    3. Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation. Biswas B, et al. Am J Reprod Immunol, 2009 Oct. PMID 19703144
    4. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, et al. J Am Soc Nephrol, 2008 Apr. PMID 18256364, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    toll-like receptor 11
    NP_001138251.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144779.2 → NP_001138251.2  toll-like receptor 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      B8YJH0, F7EMB9
      Related
      ENSRNOP00000051449.4, ENSRNOT00000039925.6
      Conserved Domains (4) summary
      cd00116
      Location:179 → 427
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:224 → 246
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13676
      Location:781 → 861
      TIR_2; TIR domain
      pfam13855
      Location:366 → 426
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26018987..26023426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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