Ugt1a8 UDP glucuronosyltransferase family 1 member A8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ugt1a8provided by RGD
Official Full Name: UDP glucuronosyltransferase family 1 member A8provided by RGD
Primary source: RGD:708474
See related: EnsemblRapid:ENSRNOG00000018740 AllianceGenome:RGD:708474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ugt1; Ugt1a9; UDPGT 1-8
Summary: Enables glucuronosyltransferase activity. Involved in cellular response to organic cyclic compound and coumarin catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in alcoholic pancreatitis and pancreatic cancer. Orthologous to several human genes including UGT1A8 (UDP glucuronosyltransferase family 1 member A8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1950.6), Kidney (RPKM 847.2) and 2 other tissues See more
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Genomic context

Location:: 9q35

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (96174899..96256264)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (88727094..88808465)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (95221474..95302822)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies of their activities and tissue expression suggest complementary functions of UGT1A8 and UGT1A7 isoforms in xenobiotic metabolism.
Title: Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94830 (e-PCR)
- UniSTS:120076

RH130767 (e-PCR)
- UniSTS:214051

D9Wox40 (e-PCR)
- UniSTS:518848

D9Mco15 (e-PCR)
- UniSTS:518638

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucuronosyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in coumarin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in liver development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glucuronidation	TAS Traceable Author Statement more info	PubMed
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 1A8

Names: A3; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1-8; UDPGT; UGT1*8; UGT1-08; UGT1.8

NP_787040.2

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175846.2 → NP_787040.2 UDP-glucuronosyltransferase 1A8 precursor

See identical proteins and their annotated locations for NP_787040.2

Status: VALIDATED

Source sequence(s)

AC120922, AY435135

UniProtKB/TrEMBL

A6JQH6, M0RB50, Q6T5E7, Q8VD44

Related

ENSRNOP00000066773.3, ENSRNOT00000071200.4

Conserved Domains (2) summary

PHA03392
Location:263 → 504

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:26 → 521

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase