NMS neuromedin S [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: NMSprovided by RGD
Full Name: neuromedin Sprovided by RGD
Primary source: RGD:1359122
See related: EnsemblRapid:ENSRNOG00000038979 AllianceGenome:RGD:1359122
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled receptor binding activity. Acts upstream of or within locomotor rhythm and neuropeptide signaling pathway. Predicted to be located in extracellular region. Orthologous to human NMS (neuromedin S). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (48665398..48676461)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (41169634..41180697)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (45605552..45616912)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU.
Title: Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.
Neuromedin S stimulates the HPA axis through the CRHR(1) pathway and evokes stereotyped behavior and anxiety through mesolimbic dopamine and corticotrophin releasing hormone release.
Title: Endocrine and behavioral effects of neuromedin S.
These results suggest that, in the rat, endogenous NMS plays an important role in the oxytocin release response to the suckling stimulus.
Title: Involvement of neuromedin S in the oxytocin release response to suckling stimulus.
NMS is implicated in the regulation of circadian rhythm and feeding behavior
Title: Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.
Neuromedins U and S may play different roles in the functional regulation of neuroendocrine axes.
Title: Expression of neuromedins S and U and their receptors in the hypothalamus and endocrine glands of the rat.
Expression in hypothalamus. Potential role of NMS in regulation of gonadotropic axis. May contribute to integration of circadian rhythms, energy balance, and reproduction.
Title: Neuromedin s as novel putative regulator of luteinizing hormone secretion.
may be a potent anorexigenic hormone in the hypothalamus, and the expression of proopiomelanocortin mRNA in the Arc and corticotropin mRNA in the paraventricular hypothalamic nucleus be be involved with appetite.
Title: Neuromedin s is a novel anorexigenic hormone.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotor rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuromedin-S

Names: neuromedin S precursor-related peptide/neuromedin S preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.