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    clec-61 VWFA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clec-61
    Official Full Name
    VWFA domain-containing protein
    Primary source
    WormBase:WBGene00014047
    Locus tag
    CELE_ZK666.7
    See related
    AllianceGenome:WB:WBGene00014047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-positive bacterium. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clec-61 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (10488730..10490537, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DUF4033 domain-containing protein Neighboring gene Na_H_antiporter domain-containing protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies on Shigella boydii infection in Caenorhabditis elegans and bioinformatics analysis of immune regulatory protein interactions. Kesika P, et al. Biochim Biophys Acta, 2012 Dec. PMID 22841995
    2. Caenorhabditis elegans mounts a p38 MAPK pathway-mediated defence to Cutibacterium acnes infection. Huang X, et al. Cell Microbiol, 2020 Oct. PMID 32543022
    3. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
    4. Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. Schulenburg H, et al. Immunobiology, 2008. PMID 18406370
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VWFA domain-containing protein
    NP_496260.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10488730..10490537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063859.5 → NP_496260.1  VWFA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23565
      Conserved Domains (2) summary
      smart00034
      Location:240 → 388
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl00057
      Location:32 → 219
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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