duo-3 OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: duo-3
Official Full Name: OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase
Primary source: WormBase:WBGene00001112
Locus tag: CELE_Y106G6H.12
See related: AllianceGenome:WB:WBGene00001112
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See duo-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 11

Sequence:: Chromosome: I; NC_003279.8 (10464289..10471056, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y106G6H.12 (e-PCR)
- UniSTS:312975

Y106G6H.13 (e-PCR)
- UniSTS:320657

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: OTU domain-containing protein;USP domain-containing protein;Ubiquitin carboxyl-terminal hydrolase

NP_001293463.1

Confirmed by transcript evidence

NP_001293464.1

Confirmed by transcript evidence

NP_001293465.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10464289..10471056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306534.2 → NP_001293463.1 Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293463.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBM0

Conserved Domains (3) summary

cd02673
Location:303 → 554

Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:812 → 922

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl19932
Location:669 → 786

OTU; OTU-like cysteine protease
NM_001306535.3 → NP_001293464.1 USP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293464.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PBZ5

Conserved Domains (3) summary

cd02673
Location:148 → 399

Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:657 → 767

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl19932
Location:514 → 631

OTU; OTU-like cysteine protease
NM_001306536.3 → NP_001293465.1 OTU domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293465.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PMF4

Conserved Domains (3) summary

cd02673
Location:79 → 238

Peptidase_C19Q; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:496 → 606

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl19932
Location:353 → 470

OTU; OTU-like cysteine protease