dnj-12 DNaJ domain (prokaryotic heat shock protein) [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dnj-12
Official Full Name: DNaJ domain (prokaryotic heat shock protein)
Primary source: WormBase:WBGene00001030
Locus tag: CELE_F39B2.10
See related: AllianceGenome:WB:WBGene00001030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase activator activity. Predicted to be involved in protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; pharynx; and reproductive system. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dnj-12 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (14757063..14758787)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals.
Title: Interaction between a J-domain co-chaperone and a specific Argonaute protein contributes to microRNA function in animals.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39B2.10 (e-PCR)
- UniSTS:310207

F39B2.11 (e-PCR)
- UniSTS:310208

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNaJ domain (prokaryotic heat shock protein)

NP_493570.1

Product from WormBase gene class dnj;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14757063..14758787

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061169.8 → NP_493570.1 DNaJ domain (prokaryotic heat shock protein) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493570.1

Status: REVIEWED

UniProtKB/TrEMBL

O45502

Conserved Domains (4) summary

cd10719
Location:136 → 201

DnaJ_zf; Zinc finger domain of DnaJ and HSP40

cd10747
Location:200 → 334

DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

PTZ00037
Location:2 → 401

PTZ00037; DnaJ_C chaperone protein; Provisional

pfam00226
Location:7 → 65

DnaJ; DnaJ domain