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    qars-1 Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 178415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qars-1
    Official Full Name
    Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase
    Primary source
    WormBase:WBGene00001336
    Locus tag
    CELE_Y41E3.4
    See related
    AllianceGenome:WB:WBGene00001336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See qars-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (15008503..15013183, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF4440 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ACB domain-containing protein;GOLD domain-containing protein;Golgi resident protein GCP60 Neighboring gene FANCD2 Neighboring gene Glycine Rich Secreted Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure networks of E. coli glutaminyl-tRNA synthetase: effects of ligand binding. Sathyapriya R, et al. Proteins, 2007 Aug 1. PMID 17444518
    2. Salmonella enterica Serovar Typhi exposure elicits deliberate physiological alterations and triggers the involvement of ubiquitin mediated proteolysis pathway in Caenorhabditis elegans. Balasubramaniam B, et al. Int J Biol Macromol, 2020 Apr 15. PMID 31987945
    3. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Simmer F, et al. PLoS Biol, 2003 Oct. PMID 14551910, Free PMC Article
    4. Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex. Havrylenko S, et al. J Biol Chem, 2011 Aug 12. PMID 21685384, Free PMC Article
    5. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase
    NP_001255843.1
    • Confirmed by transcript evidence
    NP_001255844.1
    • Confirmed by transcript evidence
    NP_001255845.1
    • Confirmed by transcript evidence
    NP_001263821.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      15008503..15013183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268914.5 → NP_001255843.1  putative glutamine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62431
      Conserved Domains (5) summary
      PLN02859
      Location:1 → 785
      PLN02859; glutamine-tRNA ligase
      cd00807
      Location:269 → 573
      GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
      pfam03950
      Location:571 → 761
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      pfam04557
      Location:162 → 262
      tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
      pfam04558
      Location:7 → 159
      tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1

    2. NM_001276892.4 → NP_001263821.1  Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAI0
      Conserved Domains (1) summary
      PRK05347
      Location:1 → 205
      PRK05347; glutaminyl-tRNA synthetase; Provisional

    3. NM_001268915.3 → NP_001255844.1  glutamine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT95
      Conserved Domains (4) summary
      cd00807
      Location:43 → 347
      GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
      PRK05347
      Location:42 → 553
      PRK05347; glutaminyl-tRNA synthetase; Provisional
      pfam03950
      Location:345 → 535
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      pfam04557
      Location:1 → 36
      tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2

    4. NM_001268916.3 → NP_001255845.1  Glutaminyl-tRNA synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT96
      Conserved Domains (2) summary
      pfam03950
      Location:201 → 391
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      cl00015
      Location:58 → 203
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62431.1

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