vha-5 V-type proton ATPase 116 kDa subunit a 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vha-5
Official Full Name: V-type proton ATPase 116 kDa subunit a 2
Primary source: WormBase:WBGene00006914
Locus tag: CELE_F35H10.4
See related: AllianceGenome:WB:WBGene00006914
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase binding activity. Involved in several processes, including collagen and cuticulin-based cuticle development; exosomal secretion; and multicellular organismal-level water homeostasis. Located in apical plasma membrane; cell body membrane; and cytoplasmic vesicle. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including excretory cell; hypodermis; neuronal sheath cell; rectum; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; renal tubular acidosis; and wrinkly skin syndrome. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vha-5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (8303968..8307369)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in the V0 "a" subunit VHA-5 affect either the V0-specific function or the V0+V1 function of the V-ATPase, establishing that the V0 sector mediates secretion of Hedgehog-related proteins.
Title: The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35H10.4 (e-PCR)
- UniSTS:310142

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen and cuticulin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exosomal secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase 116 kDa subunit a 2

NP_501399.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8303968..8307369

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068998.10 → NP_501399.1 V-type proton ATPase 116 kDa subunit a 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501399.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEK9

Conserved Domains (2) summary

COG1269
Location:35 → 864

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:28 → 863

V_ATPase_I; V-type ATPase 116kDa subunit family