U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    aat-1 Large neutral amino acids transporter small subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 177793, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    aat-1
    Official Full Name
    Large neutral amino acids transporter small subunit 1
    Primary source
    WormBase:WBGene00000002
    Locus tag
    CELE_F27C8.1
    See related
    AllianceGenome:WB:WBGene00000002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Is expressed in several structures, including excretory system; nervous system; pharynx; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; lung squamous cell carcinoma; and lysinuric protein intolerance. Orthologous to several human genes including SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See aat-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (9599178..9601695, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter. Lin L, et al. Genes Dev, 2020 Aug 1. PMID 32675325, Free PMC Article
    2. D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Weimer S, et al. Nat Commun, 2014 Apr 8. PMID 24714520, Free PMC Article
    3. Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. Caito SW, et al. Biochem Biophys Res Commun, 2013 Jun 14. PMID 23669041, Free PMC Article
    4. Aromatic amino acid transporter AAT-9 of Caenorhabditis elegans localizes to neurons and muscle cells. Veljkovic E, et al. J Biol Chem, 2004 Nov 19. PMID 15364921
    5. Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Gibson CL, et al. PLoS Genet, 2018 Mar. PMID 29590100, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
      Title: Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of amino acid transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Large neutral amino acids transporter small subunit 1
    NP_501707.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9599178..9601695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069306.7 → NP_501707.1  Large neutral amino acids transporter small subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19834
      Conserved Domains (1) summary
      TIGR00911
      Location:2 → 491
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools