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    klf-2 Kruppel-like factor 2 [ Caenorhabditis elegans ]

    Gene ID: 186179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klf-2
    Official Full Name
    Kruppel-like factor 2
    Primary source
    WormBase:WBGene00009998
    Locus tag
    CELE_F53F8.1
    See related
    AllianceGenome:WB:WBGene00009998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of lipid metabolic process. Predicted to be located in nucleus. Is expressed in intestine. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klf-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (20685683..20688830)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Activin_recp domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Krüppel-like family of transcription factors: an emerging new frontier in fat biology. Brey CW, et al. Int J Biol Sci, 2009 Oct 1. PMID 19841733, Free PMC Article
    2. Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage. Ling J, et al. Nutr Metab (Lond), 2017. PMID 28261316, Free PMC Article
    3. KLF regulation of insulin pathway genes. Wang H, et al. 3 Biotech, 2023 Mar. PMID 36816753, Free PMC Article
    4. Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant. Defoort J, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29873777, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kruppel-like factor 2
    NP_507995.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20685683..20688830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075594.4 → NP_507995.2  Kruppel-like factor 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507995.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62259
      Conserved Domains (1) summary
      sd00017
      Location:205 → 222
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62259.2

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