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    arl-6 ADP-ribosylation factor-like protein 6 [ Caenorhabditis elegans ]

    Gene ID: 183311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arl-6
    Official Full Name
    ADP-ribosylation factor-like protein 6
    Primary source
    WormBase:WBGene00000193
    Locus tag
    CELE_C38D4.8
    See related
    AllianceGenome:WB:WBGene00000193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activity. Involved in intracellular transport. Located in axoneme; cytosol; and dendrite. Is expressed in nervous system. Used to study Bardet-Biedl syndrome and ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See arl-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (4812481..4814830, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein pal-1 Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein Neighboring gene Membrane transporter protein Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding. Akella JS, et al. Elife, 2020 Feb 26. PMID 32101165, Free PMC Article
    2. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Fan Y, et al. Nat Genet, 2004 Sep. PMID 15314642
    3. A cilia-independent function of BBSome mediated by DLK-MAPK signaling in C. elegans photosensation. Zhang X, et al. Dev Cell, 2022 Jun 20. PMID 35649417, Free PMC Article
    4. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    5. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response HEP PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 6
    NP_497993.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4812481..4814830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065592.3 → NP_497993.1  ADP-ribosylation factor-like protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18510
      Conserved Domains (2) summary
      cd04157
      Location:19 → 180
      Arl6; Arf-like 6 (Arl6) GTPase
      TIGR00231
      Location:17 → 173
      small_GTP; small GTP-binding protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18510.1

    Gene LinkOut

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