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    pqm-1 Zinc finger transcription factor pqm-1 [ Caenorhabditis elegans ]

    Gene ID: 174705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pqm-1
    Official Full Name
    Zinc finger transcription factor pqm-1
    Primary source
    WormBase:WBGene00004096
    Locus tag
    CELE_F40F8.7
    See related
    AllianceGenome:WB:WBGene00004096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin insulator sequence binding activity. Involved in several processes, including defense response to other organism; positive regulation of macromolecule biosynthetic process; and regulation of vitellogenesis. Located in cytoplasm and nucleus. Is expressed in head muscle; intestine; neurons; and pseudocoelom. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pqm-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11150391..11152595, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Fatty-acid and retinol-binding protein 1 Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health. Jones LM, et al. Biol Chem, 2020 Aug 27. PMID 32142470
    2. Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans. Li YH, et al. Oncotarget, 2016 Apr 12. PMID 27027346, Free PMC Article
    3. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Templeman NM, et al. Curr Biol, 2018 Mar 5. PMID 29478855, Free PMC Article
    4. Selective Destabilization of Transcripts by mRNA Decapping Regulates Oocyte Maturation and Innate Immunity Gene Expression during Ageing in C. elegans. Borbolis F, et al. Biology (Basel), 2023 Jan 21. PMID 36829450, Free PMC Article
    5. DAF-16 and PQM-1: partners in longevity. Tepper RG, et al. Aging (Albany NY), 2014 Jan. PMID 24398388, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.
      Title: ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia.
    2. PQM-1 controls hypoxic survival via regulation of lipid metabolism.
      Title: PQM-1 controls hypoxic survival via regulation of lipid metabolism.
    3. nhr-14 loss upregulates the intestinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants. nhr-14 mutants display increased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to Pseudomonas aeruginosa. These responses are dependent on the transcription factor PQM-1, which localizes to intestinal cell nuclei in nhr-14 mutants.
      Title: NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.
    4. PQM-1 coordinates neuron-activated transcellular chaperone signaling via the innate immunity-associated transmembrane protein CLEC-41, whereas intestine-activated transcellular chaperone signaling depends on the aspartic protease ASP-12.
      Title: A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis.
    5. Data suggest that PQM-1 plays a central role in wide range of key biological phenomena, including normal development and aging, and the regulation of daf-2/IIS-mediated longevity.
      Title: PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular oxygen homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger transcription factor pqm-1
    NP_496391.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11150391..11152595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063990.6 → NP_496391.1  Zinc finger transcription factor pqm-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496391.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFY7
      Conserved Domains (1) summary
      pfam00096
      Location:228 → 249
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFY7.1

    Gene LinkOut

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