pos-1 RNA-binding protein pos-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pos-1
Official Full Name: RNA-binding protein pos-1
Primary source: WormBase:WBGene00004078
Locus tag: CELE_F52E1.1
See related: AllianceGenome:WB:WBGene00004078
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA 3'-UTR binding activity; poly(U) RNA binding activity; and transcription corepressor activity. Involved in several processes, including cell fate specification; embryonic pattern specification; and negative regulation of transcription by RNA polymerase II. Located in P granule. Is expressed in several structures, including AB; EMS; P4; germ line; and oocyte. Orthologous to human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pos-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 2

Sequence:: Chromosome: V; NC_003283.11 (8414086..8415254)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The polo-like kinase PLK-1 mediates the repulsive coupling between MEX-5 and POS-1 by increasing the mobility of POS-1 in the anterior.
Title: Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.
POS-1 binds the neg-1 3' UTR to oppose GLD-2 and GLD-3 activities that promote NEG-1 expression
Title: POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
POS-1 regulates glp-1 mRNA translation by blocking access of other RNA-binding proteins to a key regulatory sequence.
Title: POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.
The POS-1 recognition element is found within the 3' untranslated region of 227 maternal transcripts required for early development, including genes involved in endoderm and germline specification.
Title: RNA target specificity of the embryonic cell fate determinant POS-1.
the balance between POS-1 and SPN-4 controls the translation of maternal glp-1 mRNA
Title: Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52E1.1 (e-PCR)
- UniSTS:306384

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding protein pos-1

NP_001379937.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8414086..8415254

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392561.1 → NP_001379937.1 RNA-binding protein pos-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF15

Conserved Domains (2) summary

COG5063
Location:47 → 222

CTH1; CCCH-type Zn-finger protein [General function prediction only]

pfam00642
Location:142 → 166

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)