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    sqv-4 UDP-glucose 6-dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 179484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqv-4
    Official Full Name
    UDP-glucose 6-dehydrogenase
    Primary source
    WormBase:WBGene00005022
    Locus tag
    CELE_F29F11.1
    See related
    AllianceGenome:WB:WBGene00005022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables UDP-glucose 6-dehydrogenase activity and identical protein binding activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in cytoplasm. Is expressed in several structures, including egg-laying apparatus; germ line; hypodermis; oocyte; and spermatheca. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 84. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqv-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (10659635..10661467, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aquaporin Neighboring gene glucuronosyltransferase Neighboring gene glucuronosyltransferase Neighboring gene Cytoplasmic tRNA 2-thiolation protein 2 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
    2. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391315, Free PMC Article
    3. Mutations that perturb vulval invagination in C. elegans. Herman T, et al. Cold Spring Harb Symp Quant Biol, 1997. PMID 9598369
    4. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Sugahara K, et al. Curr Opin Struct Biol, 2003 Oct. PMID 14568617
    5. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Franks DM, et al. Dev Biol, 2006 Aug 15. PMID 16828468

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose 6-dehydrogenase
    NP_505730.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10659635..10661467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073329.11 → NP_505730.1  UDP-glucose 6-dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505730.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19905
      Conserved Domains (1) summary
      PLN02353
      Location:11 → 471
      PLN02353; probable UDP-glucose 6-dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19905.1

    Gene LinkOut

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